Table 4

Bivariate and multivariate metaregression analyses for until 6 months DAS28(CRP)

	YODA platform (3767 patients)			Vivli platform (7457 patients)
	Standardised coefficient	SD	P value	Standardised coefficient	SD	P value
Bivariate
Smoking	0.051	0.09	0.58	0.09	0.08	0.27
Exercise	−0.23	0.12	0.06
Men	−0.15	0.09	0.12	−0.26	0.07	<0.001
Age*	0.003	0.003	0.28	−0.003	0.002	0.17
BMI*	0.002	0.006	0.75	0.015	0.004	<0.001
RF+	−0.15	0.10	0.15	0.40	1.22	0.74
ACPA +	−0.18	0.11	0.11	0.27	0.29	0.36
Disease duration*	0.005	0.01	0.70	0.013	0.005	<0.001
Baseline DAS28(CRP)	0.54	0.04	<0.001	0.56	0.03	<0.001
Treatment	−0.47	0.04	<0.001	−0.63	0.03	<0.001
Treatment by covariate interaction
Treatment: smoking	−0.003	0.11	0.97	0.02	0.10	0.81
Treatment: exercise	0.054	0.14	0.71
Treatment: men	−0.11	0.11	0.32	0.14	0.08	0.08
Treatment: age	−0.0005	0.004	0.89	0.006	0.003	0.06
Treatment: BMI	0.006	0.0077	0.43	0.002	0.005	0.63
Treatment: RF+	0.02	0.12	0.86	0.85	1.34	0.53
Treatment: ACPA+	0.12	0.13	0.33	0.04	0.32	0.89
Treatment: duration	0.01	0.015	0.41	−0.02	0.005	<0.001
Treatment: baseline DAS28(CRP)	0.1	0.04	0.03	−0.04	0.03	0.22
Multivariate†
Treatment: duration	0.02	0.02	0.32	−0.02	0.006	<0.001
Treatment: baseline DAS28(CRP)	0.08	0.01	0.44	−0.02	0.04	0.7
Treatment: baseline DAS28(CRP) >5.1	0.33	0.23	0.15	−0.21	0.11	0.049

*For one unit (year, kg/m²).
†Sex, age, BMI and disease duration.
ACPA, anticitrullinated protein antibody; BMI, body mass index; CRP, C reactive protein; Baseline DAS28, DAS28(CRP) score at baseline; DAS28, Disease Activity Score on 28 joints; RF, rheumatoid factor; YODA, Yale Open Data Access.