Studies on imaging settings and technical standards (PICO2)
| Year author | Study design | Setting | Alternative setting | Disease | No Setting/ Alternative setting | Intervention (COMPOUND) | SITE | FAVORS setting* | FAVORS alternative setting* | No difference between settings* | RoB† |
| Large joints and periarticular structures | |||||||||||
| 2017 Orlandi63 | RCT | One Needle | Two Needles | Rotator cuff calcific tendinopathy | 100/111 | US aspiration/ injection (heated saline, mepivacaine, triamcinolone) | subacromial/ subdeltoid bursa | – | 2 x Efficacy (BSL) | 1 x Accuracy (BSL) 3 x Safety (BSL,1,3m,1y) 1 x Cost/Time (BSL) |  |
| 2012 Sibbitt25 | RCT | 25 mL mechanical syringe | 60 mL automatic syringe | knee effusion in rheumatoid arthritis, osteoarthritis | 20/22 | US joint aspiration/ injection (lidocaine, triamcinolone) | knee joint | – | – | 1 x Accuracy (BSL) 1 x Safety (BSL,2w) |  |
| Multiple joints | |||||||||||
| 2018 Just64 | Retrospective cohort study | US-NB | US-P&F/ Arthroscopy | Inflammatory arthritis, degenerative disease | US-NB: 402/ US-P&F: 65 Arthroscopy: 57 | Synovial biopsy | wrist, knee, MCP, ankle, elbow, MTP | – | 1 x Efficacy (n.a.) | 2 x Safety (BSL,7-14d) 2 x Efficacy (BSL,7-14d) |  |
*These columns indicate the number of outcomes studied and their categories (eg, 6 × efficacy indicates that six different outcomes related to the efficacy category were studied), with the respective time point(s) when the outcome was determined (parenthesis). The term ‘BSL’ refers to differences concerning the outcomes at BSL. A detailed description of studies and outcomes can be found in supplement.
†A green, yellow, red and black circle indicate low, moderate, high and critical risk of bias, respectively. In case multiple circles are depicted, certain outcomes within one study had different risk of bias.
BSL, baseline; MCP, metacarpophalangeal joints; MTP, metatarsophalangeal joints; n.a., not applicable; NB, needle biopsy; P&F, portal and forceps; PICO, Population, Intervention, Comparator, Outcome; RCT, randomised controlled trial; RoB, Risk of Bias; US, ultrasound.;