Table 3

Longitudinal analyses for repeated measures for association between etanercept serum concentration and response or remission

OR (95% CI)P value
EULAR good/moderate response1.37 (0.71 to 2.64)0.35
DAS28 remission0.86 (0.56 to 1.32)0.49
Ultrasound remission (PD=0)0.70 (0.46 to 1.05)0.09
SDAI remission0.99 (0.61 to 1.61)0.96
  • Mixed effect logistic regression model, adjusted for age, gender, disease duration and prior use of biological disease-modifying antirheumatic drug (yes/no). OR EULAR good/moderate response versus non-response and remission, defined by DAS28-, PD=0 or SDAI remission, vs non-remission. Interaction test of time-by-serum etanercept concentration showed that the association did not vary significantly over time.

  • DAS28, Disease Activity Score 28 joints; PD, Power Doppler; SDAI, Simplified Disease Activity Index.