Table 2

Prevalence of 44 previously published morbidities in patients with and without rheumatoid arthritis

MorbidityRA (%)Non-RA (%)OR (95% CI) RA versus Non-RAQ-value
Multimorbidity (2+)1411 (85.9)1164 (70.8)2.80 (2.33 to 3.38)<0.001
Multimorbidity (5+)907 (55.2)619 (37.7)2.37 (2.03 to 2.77)<0.001
Interstitial lung disease82 (5.0)28 (1.7)3.11 (2.03 to 4.90)<0.001
Fibromyalgia153 (9.3)53 (3.2)3.11 (2.27 to 4.32)<0.001
Post-traumatic stress disorder18 (1.1)6 (0.4)3.06 (1.27 to 8.47)0.057
Osteoarthritis668 (40.7)335 (20.4)2.95 (2.51 to 3.48)<0.001
Osteoporosis256 (15.6)110 (6.7)2.92 (2.28 to 3.77)<0.001
Drugs31 (1.9)12 (0.7)2.64 (1.38 to 5.37)0.017
Chronic back pain656 (39.9)378 (23)2.28 (1.95 to 2.66)<0.001
Pulmonary circulation disorders60 (3.7)28 (1.7)2.21 (1.41 to 3.53)0.003
Neuropathy237 (14.4)123 (7.5)2.09 (1.67 to 2.64)<0.001
Liver disease55 (3.3)28 (1.7)2.00 (1.27 to 3.21)0.012
Anaemia330 (20.1)206 (12.5)1.81 (1.49 to 2.20)<0.001
Chronic obstructive pulmonary disease117 (7.1)69 (4.2)1.77 (1.31 to 2.42)0.001
Peripheral vascular disease/aneulcer disurysm206 (12.5)133 (8.1)1.73 (1.36 to 2.21)<0.001
Peptic ulcer disease17 (1)10 (0.6)1.71 (0.79 to 3.89)0.33
Sleep disorder174 (10.6)107 (6.5)1.70 (1.33 to 2.20)<0.001
Severe vision reduction551 (33.5)412 (25.1)1.68 (1.42 to 1.99)<0.001
Hypothyroid355 (21.6)240 (14.6)1.65 (1.37 to 1.98)<0.001
Bipolar16 (1)10 (0.6)1.61 (0.74 to 3.69)0.38
Depression388 (23.6)268 (16.3)1.60 (1.34 to 1.91)<0.001
Chronic headache169 (10.3)113 (6.9)1.56 (1.22 to 2.01)0.002
Gout59 (3.6)39 (2.4)1.54 (1.03 to 2.35)0.11
Gastro-oesophageal reflux disease294 (17.9)206 (12.5)1.53 (1.26 to 1.86)<0.001
Congestive heart failure101 (6.1)70 (4.3)1.52 (1.10 to 2.10)0.040
Asthma155 (9.4)107 (6.5)1.50 (1.16 to 1.94)0.008
Coronary artery disease225 (13.7)166 (10.1)1.49 (1.18 to 1.87)0.003
Hypertension815 (49.6)692 (42.1)1.47 (1.26 to 1.71)<0.001
Urinary incontinence76 (4.6)55 (3.3)1.42 (0.99 to 2.04)0.15
Dementia7 (0.4)5 (0.3)1.41 (0.45 to 4.83)0.72
Inflammatory skin diseases128 (7.8)93 (5.7)1.41 (1.07 to 1.86)0.049
Cardiac arrhythmias249 (15.2)191 (11.6)1.40 (1.14 to 1.74)0.007
Diverticulitis/diverticulosis76 (4.6)58 (3.5)1.33 (0.94 to 1.90)0.25
Alcohol abuse29 (1.8)22 (1.3)1.33 (0.76 to 2.35)0.49
Cerebrovascular disease83 (5.1)68 (4.1)1.25 (0.89 to 1.75)0.35
Valvular heart disease98 (6)83 (5.1)1.20 (0.89 to 1.64)0.38
Anxiety158 (9.6)134 (8.2)1.20 (0.94 to 1.53)0.27
Prostatic hyperplasia58 (12.4)51 (10.9)1.18 (0.77 to 1.80)0.63
Hyperlipidaemia745 (45.3)707 (43)1.12 (0.96 to 1.29)0.29
Parkinson’s disease13 (0.8)12 (0.7)1.09 (0.49 to 2.44)0.89
Obesity*696 (42.4)664 (40.4)1.08 (0.94 to 1.25)0.40
Hearing loss124 (7.5)116 (7.1)1.08 (0.82 to 1.41)0.72
Non-inflammatory gynecologic disorders186 (15.8)180 (15.3)1.04 (0.83 to 1.31)0.82
Renal disease84 (5.1)81 (4.9)1.04 (0.76 to 1.44)0.87
Diabetes260 (15.8)267 (16.3)0.97 (0.80 to 1.17)0.83
Cancer124 (7.5)131 (8)0.94 (0.73 to 1.22)0.77
  • *Obesity was defined as subjects having either two codes ≥30 days apart or having a body mass index ≥30 kg/m2 on 1 January 2015.

  • RA, rheumatoid arthritis.