Table 1

COBRA light therapy schedule

Week 1Methotrexate 10 mg/week + prednisone 30 mg/day
Week 2Methotrexate 10 mg/week + prednisone 20 mg/day
Week 3Methotrexate 10 mg/week + prednisone 15 mg/day
Week 4–7Methotrexate 17.5 mg/week + prednisone 10 mg/day
Week 8Methotrexate 25 mg/week + prednisone 10 mg/day
Week 9–12Methotrexate 25 mg/week + prednisone 7.5 mg/day

  • Note: patients also received 5 mg of folic acid weekly.