Allergy type | No (%) | Adjusted* OR (95% CI) | |||
RA cases (N=3515) | Controls (N=5429) | All RA (N=3515) | ACPA +RA (N=2262) | ACPA- RA (N=1165) | |
Animal dander† | 89 (6) | 134 (5) | 1.37 (1.03 to 1.82) | 1.46 (1.06 to 2.01) | 1.17 (0.73 to 1.88) |
Allergic rhinitis | 270 (9) | 387 (8) | 1.30 (1.00 to 1.68)‡ | 1.24 (0.90 to 1.70)‡ | 1.39 (0.97 to 2.00)‡ |
Atopic dermatitis | 345 (11) | 453 (10) | 1.16 (0.98 to 1.25)§* | 0.99 (0.83 to 1.18) | 1.32 (1.06 to 1.65)§* |
Metal allergy† | 43 (3) | 58 (2) | 1.27 (0.84 to 1.91) | 1.23 (0.77 to 1.98) | 1.54 (0.83 to 2.83) |
Respiratory allergy† | 154 (11) | 271 (9) | 1.11 (0.90 to 1.38) | 1.15 (0.90 to 1.47) | 0.98 (0.69 to 1.39) |
Food allergy† | 19 (1.4) | 40 (1.5) | 1.01 (0.58 to 1.76) | 1.04 (0.55 to 1.97) | 1.04 (0.43 to 2.48) |
Plants and pollen† | 130 (9) | 293 (10) | 0.94 (0.75 to 1.18) | 0.96 (0.74 to 1.24) | 0.91 (0.64 to 1.31) |
Allergy to chemicals† | 24 (1.8) | 51 (1.9) | 0.85 (0.51 to 1.40) | 0.81 (0.45 to 1.48) | 0.82 (0.36 to 1.83) |
*Adjusting for age, sex, residential area, body mass index, education and smoking. Bold values are statistically significant (p<0.05).
†Data only available for the first version of questionnaire, 2006 and prior, N=1884 RA cases and N=2146 controls.
‡Interaction term with smoking was significant (p<0.05). OR shown assumes most common scenario (never smoker).
§Interaction term with age was significant (p<0.05). OR shown assumes median age (55 years).
ACPA, anticitrullinated peptide antibodies; EIRA, Epidemiological Investigation of Rheumatoid Arthritis; RA, rheumatoid arthritis.