Tissue outcome and tolerance of sequential synovial biopsies
| US-NB* | US-P&F* | A* | |
Tissue yield and quality:
| = | = | = |
| RNA yield Small joints RNA yield Large joints15 | US-NB1 >US-NB2: p=0.026 | – | – |
| – | US-P&F1>US P&F2: p<0.001 | A1 <A2: p<0.001 | |
| RNA quality (RIN) Small and large joints15 | = | = | = |
| Immune cell infiltrate and pathotype15 | = | = | = |
| Tolerance VAS pain, swelling, stiffness16 | = | = | = |
| Willingness to repeat16 | = | ||
| Adverse events16 | = | ||
*First biopsy is the reference in this table.
A, arthroscopy; NB, needle biopsy; P&F, portal and forceps; RIN, RNA integrity number; ST, synovial tissue; US, ultrasound; VAS, visual analogic scale