Age at RA onset according to smoking status among women in the E3N cohort (N=79 806)
| Smoking status | RA, N | Age at RA, years | P value |
| According to passive smoking in childhood | 0.0015 | ||
| Never smoker, no passive smoking in childhood | 293 | 65.1 (9.3) | |
| Never smoker, passive smoking in childhood | 57 | 64.2 (8.9) | |
| Ever smoker, no passive smoking in childhood | 291 | 63.0 (8.6) | |
| Ever smoker, passive smoking in childhood | 57 | 60.6 (9.0) | |
| According to passive smoking in adulthood | 0.0002 | ||
| Never smoker, no passive smoking in adulthood | 175 | 66.3 (9.0) | |
| Never smoker, passive smoking in adulthood | 175 | 63.5 (9.2) | |
| Ever smoker, no passive smoking in adulthood | 122 | 63.0 (10.0) | |
| Ever smoker, passive smoking in adulthood | 226 | 62.4 (7.9) | |
| According to passive smoking in childhood and/or adulthood | 0.001 | ||
| Never smoker, no passive smoking in childhood, no passive smoking in adulthood | 149 | 66.5 (9.3) | |
| Never smoker, no passive smoking in childhood, passive smoking in adulthood | 144 | 63.5 (9.0) | |
| Never smoker, passive smoking in childhood, no passive smoking in adulthood | 26 | 64.6 (7.3) | |
| Never smoker, passive smoking in childhood, passive smoking in adulthood | 31 | 63.7 (10.2) | |
| Ever smoker, no passive smoking in childhood, no passive smoking in adulthood | 107 | 63.4 (10.1) | |
| Ever smoker, no passive smoking in childhood, passive smoking in adulthood | 184 | 62.8 (7.5) | |
| Ever smoker, passive smoking in childhood, no passive smoking in adulthood | 15 | 60.3 (8.8) | |
| Ever smoker, passive smoking in childhood, passive smoking in adulthood | 42 | 60.7 (9.2) | |
| According to passive smoking in childhood and/or adulthood | <0.001 | ||
| Never smoker, no passive smoking in childhood and/or in adulthood | 149 | 66.5 (9.3) | |
| Never smoker, passive smoking in childhood and/or in adulthood | 201 | 63.7 (9.0) | |
| Ever smoker, no passive smoking in childhood and/or passive smoking in adulthood | 107 | 63.4 (9.0) | |
| Ever smoker, passive smoking in childhood and/or passive smoking in adulthood | 31 | 62.3 (8.0) |
Results are expressed as N for categorical variables and mean (SD) for continuous variables.
E3N, Etude Epidémiologique auprès des femmes de la Mutuelle générale de l’Education Nationale; RA, rheumatoid arthritis.