Comparison of pain, function and quality of life in patients with knee osteoarthritis with or without central sensitisation
| QoL measures | Widespread pain | Lowest 10th percentile of PPTarm | PainDETECT (≥13/38) | |||
| No (n=216) | Yes (n=17) | No (n=206) | Yes (n=27) | No (n=222) | Yes (n=11) | |
| WOMAC pain | 41.0 (18.1) | 50.6 (14.2)* | 41.2 (18.3) | 45.6 (15.8) | 40.5 (17.3) | 65.9 (14.8)** |
| WOMAC function | 34.4 (17.8) | 43.0 (17.5) | 34.2 (18.0) | 41.1 (15.7)* | 33.9 (17.0) | 57.0 (22.3)** |
| SF-36 domains | ||||||
| PF | 38.2 (21.8) | 35.6 (17.3) | 38.7 (21.8) | 32.8 (17.8) | 38.8 (21.3) | 22.3 (19.2)* |
| RP | 20.6 (32.9) | 5.9 (16.6)* | 20.3 (32.2) | 13.9 (32.0) | 19.7 (32.6) | 15.9 (23.1) |
| BP | 35.6 (19.2) | 27.5 (13.9)** | 35.1 (19.5) | 34.0 (14.7) | 35.5 (19.1) | 24.2 (13.3) |
| GH | 68.5 (20.8) | 64.5 (23.1) | 69.4 (20.6) | 59.3 (22.4)* | 68.7 (20.7) | 58.4 (25.7) |
| VT | 68.8 (22.4) | 59.4 (21.6) | 68.8 (22.5) | 63.1 (21.1) | 69.0 (21.8) | 51.8 (29.2)* |
| SF | 56.8 (37.4) | 50.0 (40.5) | 57.3 (38.0) | 48.1 (33.7) | 56.7 (37.7) | 47.7 (42.1) |
| RE | 85.8 (34.2) | 86.3 (33.5) | 86.7 (33.5) | 79.0 (38.3) | 86.9 (32.9) | 63.6 (50.5) |
| MH | 81.9 (16.2) | 78.1 (22.7) | 82.2 (16.8) | 77.8 (15.8) | 82.2 (16.3) | 70.2 (22.2)* |
| PCS | 32.3 (10.0) | 30.4 (6.5) | 32.4 (9.8) | 30.6 (9.7) | 32.4 (9.9) | 28.8 (8.7) |
| MCS | 52.5 (10.4) | 48.5 (11.4)* | 52.7 (10.6) | 48.5 (9.2) | 52.6 (10.2) | 44.2 (13.7)** |
Bold: statistically significant; data shown as mean (SD).
*P<0.05; **p<0.01.
BP, bodily pain; GH, general health perceptions; MCS, mental component summary; MH, mental health; PCS, physical component summary; PF, physical functioning; PPTarm, pressure pain threshold taken at volar side of right forearm; RE, emotional role limitations; RP, physical role limitations; SF, social functioning; SF-36, Medical Outcome Survey Short-form 36; VT, vitality; WOMAC, Western Ontario and McMaster University Index.