Table 2

Univariable associations between HLA-B27 and positive family history stratified by geographical region

OR (95% CI)P value
Positive family history of axSpA
 Total population
  Present518901.84 (1.43 to 2.38)<0.001
 Per geographical region
  Asia144/48711/584.19 (2.24 to 7.83)<0.001
  Europe and North America196/65830/1822.09 (1.40 to 3.13)<0.001
  Latin America37/1643/383.95 (1.21 to 12.89)0.023
  Middle East and North Africa141/30046/1610.98 (0.69 to 1.40)0.917
Positive family history of uveitis
 Total population
  Present66101.81 (0.92 to 3.56)0.084
 Per geographical region
  Europe and North America28/6585/1821.54 (0.59 to 4.01)0.379
  Latin America6/1641/381.65 (0.20 to 13.72)0.644
  Middle East and North Africa20/3004/1611.37 (0.47 to 4.04)0.565
Positive family history of ReA
 Total population
  Present1431.26 (0.36 to 4.40)0.719
 Per geographical region
  Europe and North America5/6581/1821.35 (0.16 to 11.58)0.785
  Latin America2/1640/38n.a.n.a.
  Middle East and North Africa2/3002/1610.27 (0.04 to 1.92)0.191
Positive family history of IBD
 Total population
  Present47270.45 (0.28 to 0.74)0.001
 Per geographical region
  Europe and North America34/65817/1820.52 (0.29 to 0.94)0.030
  Latin America0/1643/38n.a.n.a.
  Middle East and North Africa13/3006/1610.56 (0.21 to 1.49)0.247
Positive family history of psoriasis
 Total population
  Present148570.68 (0.49 to 0.94)0.020
 Per geographical region
  Europe and North America98/65834/1820.75 (0.50 to 1.13)0.172
  Latin America13/1644/380.85 (0.28 to 2.62)0.777
  Middle East and North Africa28/30019/1610.39 (0.21 to 0.70)0.002
  • axSpA, axial spondyloarthritis; HLA-B27, human leucocyte antigen B27; IBD, inflammatory bowel disease; n.a., not available; ReA, reactive arthritis; Ref, reference category.