Change in SU concentration, mean CCA-IMT and hs-CRP level with febuxostat treatment over 24 months
| Variable | Estimated mean value | 95% CI |
| SU, mg/dL | ||
| At 12 months | 4.986 | 4.814 to 5.158 |
| Change from baseline to 12 months | ‒2.672 | ‒2.845 to ‒2.499 |
| At 24 months | 4.606 | 4.437 to 4.775 |
| Change from baseline to 24 months | ‒3.051 | ‒3.221 to ‒2.882 |
| Mean CCA-IMT, mm | ||
| At 12 months | 0.818 | 0.804 to 0.831 |
| Change from baseline to 12 months | 0.004 | ‒0.009 to 0.017 |
| At 24 months | 0.820 | 0.807 to 0.833 |
| Change from baseline to 24 months | 0.006 | ‒0.006 to 0.019 |
| Logarithmic hs-CRP | ||
| At 12 months | 6.681 | 6.533 to 6.829 |
| Change from baseline to 12 months | 0.203 | 0.054 to 0.351 |
| At 24 months | 6.651 | 6.506 to 6.797 |
| Change from baseline to 24 months | 0.173 | 0.027 to 0.318 |
CCA-IMT, common carotid artery intima–media thickness; hs-CRP, high-sensitivity C reactive protein; SU, serum urate.