Table 2

Frequency of (systemic) adverse events (AEs) for the total group and split for Pfizer-BioNtech, AstraZeneca and Moderna

First vaccinationSecond vaccination
All vaccine typespSS (n=67)HC (n=33)P valuepSS (n=66)HC (n=25)P value
Presence of any systemic AE34 (51)16 (48)0.8341 (62)14 (56)0.59
Presence of any AE37 (55)18 (55)0.9542 (64)15 (60)0.75
 Arthralgia7 (11)1 (3)0.268 (12)3 (12)1.00
 Fatigue26 (39)12 (36)0.7736 (55)13 (52)0.83
 Cold shivers9 (14)5 (15)1.009 (14)5 (20)0.52
 Fever2 (3)2 (6)0.604 (6)4 (16)0.21
 Headache23 (35)10 (30)0.6525 (38)8 (32)0.57
 Myalgia20 (30)10 (30)0.9619 (29)10 (40)0.31
 Nausea5 (8)2 (6)1.006 (9)3 (13)0.70
Pfizer/BiontechpSS (n=47)HC (n=14)P valuepSS (n=47)HC (n=13)P value
Presence of any systemic AE21 (45)3 (21)0.2127 (57)5 (38)0.35
Presence of any AE24 (51)3 (21)0.0728 (60)6 (46)0.39
 Arthralgia1 (2)03 (6)2 (15)
 Fatigue14 (30)3 (21)23 (49)5 (38)
 Cold shivers3 (7)04 (9)1 (8)
 Fever1 (2)01 (2)1 (8)
 Headache13 (28)1 (7)14 (30)3 (23)
 Myalgia12 (26)1 (7)13 (28)3 (23)
 Nausea002 (4)0
AstrazenecapSS (n=13)HC (n=5)P valuepSS (n=13)HC (n=4)P value
Presence of any systemic AE8 (62)3 (60)1.008 (62)1 (25)0.29
Presence of any AE8 (62)3 (60)1.008 (62)1 (25)0.29
 Arthralgia6 (46)02 (15)0
 Fatigue8 (62)2 (40)7 (54)0
 Cold shivers5 (38)1 (20)1 (8)0
 Fever1 (8)000
 Headache6 (50)3 (60)6 (46)0
 Myalgia6 (46)3 (60)2 (15)1 (25)
 Nausea3 (23)1 (20)1 (8)0
ModernapSS (n=6)HC (n=8)P valuepSS (n=6)HC (n=8)P value
Presence of any systemic AE5 (83)4 (50)0.306 (100)8 (100)
Presence of any AE5 (83)6 (75)1.006 (100)8 (100)
 Arthralgia003 (50)1 (13)
 Fatigue4 (80)1 (13)6 (100)8 (100)
 Cold shivers1 (20)1 (13)4 (67)4 (50)
 Fever003 (50)3 (38)
 Headache4 (67)2 (25)5 (83)5 (63)
 Myalgia2 (33)3 (38)4 (67)6 (75)
 Nausea2 (40)1 (13)3 (50)3 (38)
  • Data presented as n (%).

  • HC, healthy controls; pSS, primary Sjögren’s syndrome.