Table 3

Comparison of HLA-B27 and PRS of different axSpA groups, overall and separately for men and women

CasesGenderVersus nr-axSpAVersus related healthy controlsVersus unrelated healthy controls
HLA-B27PRSHLA-B27PRSHLA-B27PRS
AUCP-AUCAUCP-AUCP-PRSAUCP-AUCAUCP-AUCP-PRSAUCP-AUCAUCP-AUCP-PRS
axSpAOverall0.71400.72902.73×10−25 0.87800.92000
Female0.6550.0000100.6590.0000220.0000040.83300.86900
Male0.75100.77304.69×10−22 0.90000.94600
ASOverall0.6360.00280.6080.0260.000100.74900.77201.22×10−28 0.91300.96000
Female0.7070.00110.7110.000850.000210.7467.63×10−13 0.77401.33×10−9 0.92300.96900
Male0.5520.4280.4770.750.550.76000.78604.74×10−21 0.90900.95800
nr-axSpAOverall0.6060.00760.5910.0470.00770.7704.53×10−12 0.7971.09×10−13 8.11×10−57
Female0.5320.560.4980.980.790.7090.000160.7340.0000727.27×10−21
Male0.7030.000130.7170.000530.000150.8523.58×10−13 0.88102.91×10−41
  • AUC and p values for comparisons of AUC between groups are provided for both HLA-B27 and PRS (P-AUC), and for PRS p values from independent sample t-tests between groups (P-PRS). P=0 refers to P<10−100.

  • AS, ankylosing spondylitis; AUC, area under the curve; axSpA, axial spondyloarthritis; nr-axSpA, non-radiographic axial spondyloarthritis; PRS, polygenic risk score.