Table 3
Monogenic recurrent fever
Non monogenic SAID (n=50)Monogenic SAID (n=67)
Patient’s characterisics
Age (years)
Median (IQR)44.0 (34.0 ; 59.0)29.0 (19.0 ; 43.0)
<184/50 (8.0)13/67 (19.4)
18–6437/50 (74.0)45/67 (67.2)
≥659/50 (18.0)9/67 (13.4)
Female gender29/50 (45.3)35/67 (54.7)
Comorbidities
Respiratory disease3/50 (6.0)3/67 (4.5)
Interstitial lung disease00
COPD1/50 (2.0)1/67 (1.5)
Asthma2/50 (4.0)2/67 (3.0)
Cardiovascular disease6/50 (12.0)5/67 (7.5)
Coronary heart diseases4/50 (8.0)5/67 (7.5)
Stroke4/50 (8.0)1/67 (1.5)
Diabetes5/50 (10.0)3/67 (4.5)
BMI (kg/m²)25.0 (21.0 ; 28.0)22.0 (20.0 ; 25.5)
<3038/47 (80.9)60/64 (93.8)
30–39.96/47 (12.8)4/64 (6.3)
≥403/47 (6.4)0/64 (0.0)
Hypertension6/50 (12.0)6/67 (9.0)
Cancer2/50 (4.0)1/67 (1.5)
Smoking6/50 (12.0)2/67 (3.0)
Chronic renal failure2/50 (4.0)3/67 (4.5)
Number comorbidities, median (IQR)
025/50 (50.0)51/67 (76.1)
116/50 (32.0)10/67 (14.9)
25/50 (10.0)3/67 (4.5)
33/50 (6.0)1/67 (1.5)
41/50 (2.0)2/67 (3.0)
>400
Rheumatic or inflammatory Diseases treatments
Corticosteroid19/50 (38.0)1/67 (1.5)
Systemic corticosteroid doses≥10 mg6/19 (31.6)0/1 (0.0)
NSSAIDs1/50 (2.0)1/67 (1.5)
Colchicine15/50 (30.0)57/67 (85.1)
Hydroxychloroquine00
Methotrexate13/50 (26.0)0/67 (0.0)
Leflunomide00
Salazopyrine00
Mycophenolate Mofetil / mycophenolic acid00
Azathioprine4/50 (8.0)0/67 (0.0)
IgIV00
Targeted biologic or synthetic therapies
anti-TNF14/50 (28.0)4/67 (6.0)
anti-IL65/50 (10.0)0/67 (0.0)
anti-IL17A00
anti-IL14/50 (8.0)8/67 (11.9)
abatacept1/50 (2.0)0/67 (0.0)
JAK inhibitor1/50 (2.0)0/67 (0.0)
Other biologics1/50 (2.0)0/67 (0.0)
Severity of COVID-19 Infection
Mild35/50 (70.0)55/67 (82.1)
Moderate9/50 (18.0)8/67 (11.9)
Severe6/50 (12.0)4/67 (6.0)
Length of hospital stay (days), median (IQR)12 (6 to NA)5 (2 to NA)
Death4/50 (8.0)2/67 (3.0)