Table 6

Results of significance testing (p values) comparing withholding therapy versus continuing therapy within DMARD classes

csDMARDbDMARDtsDMARD
Detectable SARS-CoV2 IgG Abs*
 Post first vaccine dose0.0310.2740.001
 Post second vaccine dose0.5100.2850.111
Mean SARS-CoV2 IgG Ab titre†
 Post first vaccine dose0.0180.7060.000
 Post second vaccine dose0.6200.2310.001
  • *Using Fisher’s exact test with significance cut-off 5%.

  • †Using Kruskal-Wallis test among the immunosuppression groups only with significance cut-off 5%.

  • Ab, antibody; bDMARD, biologic DMARD; csDMARD, conventional synthetic DMARD; DMARD, disease-modifying antirheumatic drug; tsDMARD, targeted synthetic DMARD.