Table 2

Comparative risk of MACEs between during administration and after discontinuation of the study drug

Last study drug stopEvents (n)Person-yearsIncidence rates per 100 person-yearsIRR (95% CI)P valueHR (95% CI)P value
During administration44814 4243.11 (2.83–3.41)1 (Ref)1 (Ref)
After discontinuation20831016.71 (5.86–7.68)2.16 (1.83 to 2.55)<0.00012.32 (1.94 to 2.77)<0.0001
  • IRR (incidence rate ratio) by Poisson regression.

  • HR (hazard ratio) by Cox regression with time-varying covariate.

  • MACEs, major adverse cardiovascular events.