Comparative risk of MACEs between during administration and after discontinuation of the study drug
| Last study drug stop | Events (n) | Person-years | Incidence rates per 100 person-years | IRR (95% CI) | P value | HR (95% CI) | P value |
| During administration | 448 | 14 424 | 3.11 (2.83–3.41) | 1 (Ref) | 1 (Ref) | ||
| After discontinuation | 208 | 3101 | 6.71 (5.86–7.68) | 2.16 (1.83 to 2.55) | <0.0001 | 2.32 (1.94 to 2.77) | <0.0001 |
IRR (incidence rate ratio) by Poisson regression.
HR (hazard ratio) by Cox regression with time-varying covariate.
MACEs, major adverse cardiovascular events.