Table 2

HIV-1 positive patients seen from 2008 to 2021 on anti-TNF therapy

Patient number91011121314151617
Age at first visit353049364849365349
GenderMaleMaleFemaleMaleMaleMaleMaleFemaleFemale
EthnicityBlackHispanicBlackBlackBlackBlackHispanicBlackBlack
Rheumatic
disease
Enteropathic
arthritis (Peripheral SpA)
PsAAnkylosing spondylitis (AS)PsASeronegative RANon-radiographic axial SpAPeripheral SpANon -radiographic axial SpAPeripheral SpA
Anti-TNF
agent usage
Not takingCurrently takingNot takingCurrently takingSwitched to upadacitinibNot takingCurrently takingSwitched to secukinumabCurrently taking
Taking cARTYesYesYesYesYesYesYesYesYes
Baseline
CD4 (cells/μL)
58318561456259944013008272618
Baseline
viral (copies/mL)
1788535Undetectable4500384UndetectableUndetectableUndetectableUndetectable
Duration of anti-TNF treatment2006–20102010–present2013–20132010–present2013–2016, 2020–present2014–20142019–present2020–present2020–present
Still followedLast seen
2015
Current patientCurrent
patient
Current
patient
Current patientCurrent
patient
Current patientCurrent
patient
Current
patient
Lowest CD4 on
anti-TNF treatment (cells/μL)
40330367721759938911448151416
Highest viral load on
anti-TNF
treatment (copies/mL)
35 20043 700Undetectable45 500384UndetectableUndetectable8390Undetectable
Most recent CD4
count (cells/μL)
5837711040365266592175738862402
Most recent
HIV viral load
164 00038Undetectable14 000UndetectableUndetectableUndetectableUndetectableUndetectable
Anti-TNF agent usedAdalimumabEtanercept, adalimumabEtanerceptAdalimumab, etanerceptEtanercept,EtanerceptAdalimumabAdalimumab,Adalimumab
Other biologic/anti-JAK agents usedNoneNoneNoneNoneUpadacitinibNoneNoneSecukinumabNone
Clinical response to therapyPartialEtanercept-transient, adalimumab-goodGoodAdalimumab-transient, etanercept-goodExcellentTransientExcellentGoodGood
Complications of
biological treatment
Rising viral loadNoneNoneNoneNoneNoneNoneNoneNone
  • cART, combined antiretroviral therapy; JAK, Janus kinase; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SpA, spondyloarthritis; TNF, tumour necrosis factor.