Children of HLA-B27 positive mothers with AS are more likely to have axSpA than children of HLA-B27 positive fathers with AS
| Children with axSpA number (%) | Healthy children number (%) | Total | |
| AS fathers (n=78) | 15 (12.6%) (95% CI: 6.6% to 18.6%) | 104 (87.4%) | 119 (100%) |
| AS mothers (n=22) | 12 (41.4%) (95% CI: 22.7% to 60.1%) | 17 (58.6%) | 29 (100%) |
| Total | 27 | 121 | 148 |
| p=0.00032 |
AS by modified New York criteria.
OR 4.89 with 95% CI 1.96 to 12.23.
Mean number of children for fathers: 119/78=1.53.
Mean number of children for mothers: 29/22=1.32.
Mean number of axSpA children.
For fathers: 15/78=0.19 (95% CI 0.10–0.27).
Mean number of axSpA children.
For mothers: 12/22=0.55 (95% CI 0.33 to 0.77).
AS, ankylosing spondylitis; axSpA, axial spondyloarthritis .