Table 2

Conditional analysis result of multigene loci

CytoBandGenes in locusGeneTWAS.ZTWAS.PCond.ZCond.P
1p36.32TTC34, MMEL1, FAM213BTTC34−5.202.00E-07−5.202.00E-07
FAM213B4.301.50E-05−0.079.50E-01
MMEL14.202.30E-05−0.079.50E-01
5q21.1PPIP5K2, PAMPPIP5K23.505.30E-043.505.30E-04
PAM−3.308.10E-04−1.102.50E-01
6p21.31IP6K3, C6orf106IP6K36.903.90E-126.903.90E-12
C6orf1063.301.10E-033.301.10E-03
6p22.1PGBD1, TRIM10, TRIM27PGBD1−6.501.00E-10−6.501.00E-10
TRIM104.401.20E-052.351.90E-02
TRIM27−4.103.80E-050.049.68E-01
6p22.2HIST1H2BG, ZNF322HIST1H2BG−3.309.20E-04−2.302.08E-02
ZNF3223.701.80E-042.903.90E-03
9q33.2PHF19, TRAF1, PSMD5PHF19−5.102.80E-07−3.701.80E-04
TRAF14.302.10E-052.401.62E-02
PSMD53.801.70E-04−0.248.10E-01
11q12.2TMEM258, FADS1TMEM258−4.801.90E-06−4.801.90E-06
FADS1−4.605.30E-060.079.50E-01
12q13.2SUOX, RPS26SUOX5.407.00E-085.407.00E-08
RPS26−5.104.20E-07−0.139.00E-01
12q14.1TSPAN31, METTL21BTSPAN314.409.60E-064.409.60E-06
METTL21B−4.401.10E-05−1.301.80E-01
16p11.2SPNS1, RNF40SPNS14.203.20E-054.203.30E-05
RNF403.901.10E-043.901.10E-04
17q21.1ORMDL3, IKZF3, GSDMBORMDL3−5.601.60E-08−5.601.60E-08
IKZF35.602.30E-080.764.50E-01
GSDMB−5.405.30E-080.148.90E-01
  • *Bold gene was the independent Transcriptome-wide association study signal in the locus.

  • Cond.P, p values of the gene after conditional analysis; Cond.Z, Z-score of the gene after conditional analysis; FUSION, Functional Summary-based Imputation; TWAS, transcriptome-wide association study; TWAS.P, p values of the gene in FUSION TWAS analysis; TWAS.Z, Z-score of the gene in FUSION TWAS analysis.