Conditional analysis result of multigene loci
CytoBand | Genes in locus | Gene | TWAS.Z | TWAS.P | Cond.Z | Cond.P |
1p36.32 | TTC34, MMEL1, FAM213B | TTC34 | −5.20 | 2.00E-07 | −5.20 | 2.00E-07 |
FAM213B | 4.30 | 1.50E-05 | −0.07 | 9.50E-01 | ||
MMEL1 | 4.20 | 2.30E-05 | −0.07 | 9.50E-01 | ||
5q21.1 | PPIP5K2, PAM | PPIP5K2 | 3.50 | 5.30E-04 | 3.50 | 5.30E-04 |
PAM | −3.30 | 8.10E-04 | −1.10 | 2.50E-01 | ||
6p21.31 | IP6K3, C6orf106 | IP6K3 | 6.90 | 3.90E-12 | 6.90 | 3.90E-12 |
C6orf106 | 3.30 | 1.10E-03 | 3.30 | 1.10E-03 | ||
6p22.1 | PGBD1, TRIM10, TRIM27 | PGBD1 | −6.50 | 1.00E-10 | −6.50 | 1.00E-10 |
TRIM10 | 4.40 | 1.20E-05 | 2.35 | 1.90E-02 | ||
TRIM27 | −4.10 | 3.80E-05 | 0.04 | 9.68E-01 | ||
6p22.2 | HIST1H2BG, ZNF322 | HIST1H2BG | −3.30 | 9.20E-04 | −2.30 | 2.08E-02 |
ZNF322 | 3.70 | 1.80E-04 | 2.90 | 3.90E-03 | ||
9q33.2 | PHF19, TRAF1, PSMD5 | PHF19 | −5.10 | 2.80E-07 | −3.70 | 1.80E-04 |
TRAF1 | 4.30 | 2.10E-05 | 2.40 | 1.62E-02 | ||
PSMD5 | 3.80 | 1.70E-04 | −0.24 | 8.10E-01 | ||
11q12.2 | TMEM258, FADS1 | TMEM258 | −4.80 | 1.90E-06 | −4.80 | 1.90E-06 |
FADS1 | −4.60 | 5.30E-06 | 0.07 | 9.50E-01 | ||
12q13.2 | SUOX, RPS26 | SUOX | 5.40 | 7.00E-08 | 5.40 | 7.00E-08 |
RPS26 | −5.10 | 4.20E-07 | −0.13 | 9.00E-01 | ||
12q14.1 | TSPAN31, METTL21B | TSPAN31 | 4.40 | 9.60E-06 | 4.40 | 9.60E-06 |
METTL21B | −4.40 | 1.10E-05 | −1.30 | 1.80E-01 | ||
16p11.2 | SPNS1, RNF40 | SPNS1 | 4.20 | 3.20E-05 | 4.20 | 3.30E-05 |
RNF40 | 3.90 | 1.10E-04 | 3.90 | 1.10E-04 | ||
17q21.1 | ORMDL3, IKZF3, GSDMB | ORMDL3 | −5.60 | 1.60E-08 | −5.60 | 1.60E-08 |
IKZF3 | 5.60 | 2.30E-08 | 0.76 | 4.50E-01 | ||
GSDMB | −5.40 | 5.30E-08 | 0.14 | 8.90E-01 |
*Bold gene was the independent Transcriptome-wide association study signal in the locus.
Cond.P, p values of the gene after conditional analysis; Cond.Z, Z-score of the gene after conditional analysis; FUSION, Functional Summary-based Imputation; TWAS, transcriptome-wide association study; TWAS.P, p values of the gene in FUSION TWAS analysis; TWAS.Z, Z-score of the gene in FUSION TWAS analysis.