Table 3

Effect on systolic BP and PR

VariableEstimated absolute effect (95% CI)P value
Mean systolic BP (mm Hg)
 Febuxostat versus control−2.24 (−4.33 to −0.15)0.04
 Age (per 10 years)0.53 (−0.53 to 1.59)0.32
 Male versus female−1.41 (−4.10 to 1.28)0.30
 Baseline systolic BP (per 10 mm Hg)4.46 (3.76 to 5.15)<0.001
SD of systolic BP
 Febuxostat versus control−1.16 (−2.41 to .0.09)0.07
 Age (per 10 years)0.25 (−0.38 to 0.88)0.44
 Men versus women−0.12 (−1.73 to −1.50)0.89
 Baseline systolic BP (per 10 mm Hg)0.34 (−0.08 to 0.76)0.11
CV of systolic BP
 Febuxostat versus control−0.9 (−1.7 to 0.0)0.04
 Age (per 10 years)0.2 (−0.2 to 0.7)0.25
 Male versus female−0.5 (−1.6 to 0.5)0.32
 Baseline systolic BP (per 10 mm Hg)−0.3 (−0.5 to 0.0)0.07
Mean PR (bpm)
 Febuxostat versus control−1.31 (−3.03 to 0.42)0.14
 Age (per 10 years)−0.34 (−1.24 to 0.56)0.46
 Male versus female−1.39 (−3.67 to 0.90)0.23
 Baseline PR (per 10 bpm)5.12 (4.41 to 5.84)<0.001
SD of PR
 Febuxostat versus control−1.38 (−2.72 to −0.04)0.04
 Age (per 10 years)0.65 (−0.05 to 1.34)0.07
 Male versus female−1.39 (−3.16 to 0.38)0.12
 Baseline PR (per 10 bpm)0.79 (0.24 to 1.35)0.005
CV of PR
 Febuxostat versus control−0.9 (−2.4 to 0.6)0.24
 Age (per 10 years)0.3 (−0.4 to 1.1)0.38
 Male versus female−0.9 (−2.8 to 1.1)0.38
 Baseline PR (per 10 bpm)0.6 (0.0 to 1.2)0.046

  • Estimated effects are adjusted by age, sex and baseline systolic BP or PR.

  • BP, blood pressure; CV, coefficient of variation; PR, pulse rate.