Clinical data of PsA patients with monoallelic mutations in genes associated with AD-IEI/AID
| Patient ID | Age | Sex | IEI/AID gene | Age at first diagnosis of a psoriatic manifestation | First psoriatic manifestation | Psoriatic and other manifestations of immune dysregulation | Current PsA therapy |
| 3 | 70 | F | NOD2 | 44 | Psoriasis | Plaque psoriasis, asymmetrical oligoarthritis, Crohn’s disease | Secukinumab, MTX |
| 6 | 67 | F | NOD2 | 57 | Psoriasis | Plaque psoriasis, polyarthritis | MTX |
| 11 | 49 | M | AP1S3 | 19 | Psoriasis | Plaque psoriasis and pustular psoriasis, polyarthritis, enthesitis | Ixekizumab |
| 12 | 23 | F | TNFAIP3 | 23 | Psoriasis | Plaque psoriasis, bilateral sacroiliitis, recurrent oral aphthosis | NSAID, prednisolone |
| 13 | 62 | F | AP1S3 | 24 | Psoriasis | Pustular psoriasis, sacroiliitis, polyarthritis, vitiligo | Certolizumab pegol, MTX |
| 21 | 33 | F | COPA | 18 | Arthritis | Oligoarthritis | MTX, SSZ, NSAID |
| 22 | 20 | F | TNFRSF1A | 14 | Arthritis | Oligoarthritis | Certolizumab |
| 27 | 52 | F | PLCG2 | 22 | Enthesitis | Plaque psoriasis, enthesitis, oligoarthritis | Secukinumab |
| 39 | 55 | M | AP1S3 | 33 | Psoriasis | Plaque psoriasis, polyarthritis | MTX, NSAID |
| 57 | 29 | F | NFKB1 | 3 | Psoriasis | Plaque psoriasis, treatment refractory oligoarthritis | MTX, NSAID |
| 64 | 61 | F | COPA & PLCG2 | 41 | Psoriasis | Plaque psoriasis, oligoarthritis, Crohn’s with fistulas, hypogammaglobulinemia | Infliximab |
| 65 | 34 | M | NLRP12 | 29 | Psoriasis | Plaque psoriasis, nail psoriasis, polyarthritis | Adalimumab, MTX |
| 70 | 63 | M | NLRP12 | 49 | Arthritis | Father with psoriasis and PsA, oligoarthritis, bilateral sacroiliitis | Etanercept, MTX |
| 80 | 50 | M | CARD14 & TNFAIP3 | 46 | Psoriasis | Pustular psoriasis, alopecia areata, enthesitis, oligoarthritis | Tofacitinib |
| 81 | 53 | M | NLRP12 | 54 | Arthritis | Plaque psoriasis, polyarthritis | MTX |
| 86 | 36 | F | AP1S3 | 20 | Psoriasis | Pustular psoriasis, polyarthritis | MTX, prednisolone |
| 91 | 61 | F | NOD2, IL1RN | 51 | Psoriasis | Plaque psoriasis, polyarthritis, Crohn’s disease, coeliac disease, livedo reticularis | Tofacitinib |
| 98 | 39 | F | PLCG2, DDX58 | 37 | Arthritis | Plaque psoriasis, polyarthritis, spondylitis | MTX |
| 115 | 55 | F | AP1S3 | 46 | Psoriasis | Pustular psoriasis, oligoarthritis, Grave’s disease | NSAID, prednisolone |
| 116 | 53 | F | PLCG2 | 50 | Arthritis | Oligoarthritis, hypothyroidism, polyneuropathy, atopic dermatitis, hypogammaglobulinemia | LFN, prednisolone |
F, female; LFN, leflunomide; M, male; MTX, methotrexate; NSAID, non-steroidal anti-inflammatory drug; patient ID, patient identification number; PsA, psoriatic arthritis; SSZ, sulfasalazine.