Table 3

Univariate and multivariate analyses of variables associated with the PGA

ParametersUnivariateMultivariate
P valueFirst model (any fatigue)Second model (severe fatigue)
P valueStandardised estimate (CI)P valueStandardised estimate (CI)
Age0.030.29−0.075 (−0.21 to 0.06)0.37−0.06 (−0.20 to 0.07)
Female1
Any fatigue0.0040.010.08 (0.02 to 0.14)
Severe fatigue0.0050.030.06 (0.005 to 0.12)
Anxiety0.8
Depression0.1
SELENA-SLEDAI<0.0001<0.00010.65 (0.49 to 0.82)<0.00010.65 (0.49 to 0.82)
Hydroxychloroquine0.6
Any GC0.00030.1−0.05 (−0.01 to 0.11)0.080.05 (−0.005 to 0.11)
Any IS0.0040.2−0.04 (−0.02 to 0.09)0.17−0.04 (−0.02 to 0.09)
  • Multivariate analysis adjusted for the evaluating centre. ‘–’: variables not entered in the multivariate model.

  • P values in bold indicate significance.

  • IS agents include azathioprine or methotrexate or mycophenolate or cyclophosphamide or rituximab or belimumab.

  • GC, glucocorticoids; IS, immunosuppressive agent; PGA, Physician Global Assessment; SELENA, Safety of Estrogens in Lupus Erythematosus National Assessment; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.