Table 6

Association between RA disease characteristics and sarcopenia

EWGSOP2FNIH
Crude ORs (95% CI)P valueAdjusted* ORs (95% CI)P valueCrude ORs (95% CI)P valueAdjusted* ORs (95% CI)P value
Sex
 Maleref.ref.
 Female0.56 (0.17 to 1.89)0.350.42 (0.10 to 1.79)0.34
Age (years)1.03 (0.97 to 1.08)0.361.10 (1.00 to 1.14)0.12
Height (cm)1.05 (0.99 to 1.13)0.131.08 (0.98 to 1.19)0.140.87 (0.78 to 0.96)0.0060.75 (0.64 to 0.88)0.0003
Weight (kg)0.95 (0.90 to 0.99)0.030.92 (0.86 to 0.97)0.0061.01 (0.96 to 1.01)0.611.01 (0.95 to 1.07)0.82
BMI (kg/m²)0.74 (0.62 to 0.90)0.0020.70 (0.57 to 0.87)0.0011.18 (1.02 to 1.36)0.031.20 (1.02 to 1.41)0.03
Fat mass (%)0.99 (0.92 to 1.10)0.801.00 (0.92 to 1.10)0.921.12 (1.01 to 1.25)0.041.21 (1.07 to 1.38)0.004
DAS28CRP1.34 (0.82 to 2.19)0.251.38 (0.85 to 2.24)0.191.56 (0.87 to 2.79)0.141.63 (0.93 to 2.85)0.09
CRP(mg/L)1.06 (1.02 to 1.10)0.0081.05 (1.01 to 1.10)0.021.10 (1.01 to 1.11)0.021.06 (1.01 to 1.11)0.03
Disease duration (years)1.07 (1.02 to 1.12)0.0051.08 (1.02 to 1.36)0.0061.05 (0.98 to 1.11)0.171.04 (0.97 to 1.11)0.25
CG current
 Noref.ref.ref.ref.
 Yes5.3 (1.15 to 24.4)0.035.25 (2.14 to 24.18)0.036.6 (0.80 to 54.37)0.086.5 (0.78 to 53.56)0.08
bDMARDs current
 Noref.ref.ref.ref.
 Yes2.72 (0.82 to 9.0)0.102.80 (0.84 to 9.40)0.103.6 (0.71 to 18.1)0.123.87 (0.75 to 19.95)0.11
Cumulative dose prednisone equivalent (g)1.04 (1.02 to 1.05)<0.00011.04 (1.02 to 1.05)<0.00011.02 (1.00 to 1.04)0.041.02 (1.00 to 1.04)0.05
≥1 × sports/ week
 Noref.ref.ref.ref.
 Yes0.5 (0.16 to 1.54)0.230.51 (0.17 to 1.60)0.250.26 (0.06 to 1.10)0.070.26 (0.06 to 1.13)0.07
HAQ (score 0–3)2.20 (1.17 to 4.10)0.022.50 (1.27 to 4.86)0.0082.31 (1.10 to 5.04)0.042.77 (1.17 to 6.59)0.02
ABC-scale (0–100)0.98 (0.96 to 1.00)0.110.98 (0.96 to 1.00)0.110.97 (0.95 to 1.00)0.090.98 (0.95 to 1.00)0.10
IPAQ (total METs)1.00 (1.00 to 1.00)0.261.00 (1.00 to 1.00)0.271.00 (1.00 to 1.00)0.261.00 (1.00 to 1.00)0.30
  • Bold values: p<0.05 significant.

  • *Analyses adjusted for age and sex.

  • ABC-scale, Activity-specific Balance Confidence Scale; bDMARDS, biological disease-modifying antirheumatic drugs; BMI, body mass index; CG, glucocorticoids current; CRP, C reactive protein; DAS28CRP, Disease Activity Score of 28 joints including C reactive protein; EWGSOP2, European Working Group on Sarcopenia in Older People; FNIH, Foundation for the National Institutes of Health; HAQ, Health Assessment Questionnaire; IPAQ, International Physical Activity Questionnaire; MET, metabolic equivalent; RA, rheumatoid arthritis.