Age, median (range), year | 69.5 (48–77) |
Gender | |
Male | 12 (60) |
Female | 8 (40) |
Tumour type | |
Lung | 11 (55) |
Melanoma | 7 (35) |
Renal | 1 (5) |
Lymphoma | 1 (5) |
Cancer therapy | |
Anti-PD-1 | 18 (90) |
Combination anti-CTLA-4/anti-PD-1 | 2 (10) |
Pre-existing autoimmune disease | |
No | 18 (90) |
Yes (RA) | 2 (10) |
Type of rheumatic irAE | |
RA-like | 16 (80) |
PMR-like | 2 (10) |
PsA-like | 2 (10) |
Type of bDMARD/tsDMARD used | |
Anti-IL-6R | 13 (65) |
Tocilizumab | 12 (57) |
Sarilumab | 1 (5) |
TNF inhibitors | 5 (25) |
Etanercept | 2 (9.5) |
Adalimumab | 2 (9.5) |
Infliximab | 1 (5) |
Others | 3 (15) |
Anakinra | 1 (5) |
Baricitinib | 1 (5) |
Ustekinumab | 1 (5) |
ICI discontinuation | |
No | 3 (15) |
Temporarily | 5 (25) |
Permanently* | 12 (60) |
*For other irAE (n=2: colitis and pneumonitis).
bDMARD, biologic disease-modifying antirheumatic drug; CTLA-4, cytotoxic T-lymphocyte antigen 4; ICI, immune checkpoint inhibitor; irAE, immune-related adverse event; PD-1, programmed cell death protein 1; PMR, polymyalgia rheumatica; PsA, psoriatic arthritis; RA, rheumatoid arthritis; TNF, tumour necrosis factor; tsDMARD, targeted synthetic disease-modifying antirheumatic drug.