Table 1

Patient characteristics, n (%)

Age, median (range), year69.5 (48–77)
Gender
 Male12 (60)
 Female8 (40)
Tumour type
 Lung11 (55)
 Melanoma7 (35)
 Renal1 (5)
 Lymphoma1 (5)
Cancer therapy
 Anti-PD-118 (90)
 Combination anti-CTLA-4/anti-PD-12 (10)
Pre-existing autoimmune disease
 No18 (90)
 Yes (RA)2 (10)
Type of rheumatic irAE
 RA-like16 (80)
 PMR-like2 (10)
 PsA-like2 (10)
Type of bDMARD/tsDMARD used
Anti-IL-6R13 (65)
 Tocilizumab12 (57)
 Sarilumab1 (5)
TNF inhibitors5 (25)
 Etanercept2 (9.5)
 Adalimumab2 (9.5)
 Infliximab1 (5)
Others3 (15)
 Anakinra1 (5)
 Baricitinib1 (5)
 Ustekinumab1 (5)
ICI discontinuation
 No3 (15)
 Temporarily5 (25)
 Permanently*12 (60)
  • *For other irAE (n=2: colitis and pneumonitis).

  • bDMARD, biologic disease-modifying antirheumatic drug; CTLA-4, cytotoxic T-lymphocyte antigen 4; ICI, immune checkpoint inhibitor; irAE, immune-related adverse event; PD-1, programmed cell death protein 1; PMR, polymyalgia rheumatica; PsA, psoriatic arthritis; RA, rheumatoid arthritis; TNF, tumour necrosis factor; tsDMARD, targeted synthetic disease-modifying antirheumatic drug.