Patient numbers, frequencies and scores of five radiographic features, that is, narrowing of the intervertebral space, soft tissue calcifications, vacuum phenomena, osteophytes and/or hyperostosis and spinal fusion in the cervical, thoracic and lumbosacral regions of spine in 138 patients with alkaptonuria (N=138) at the baseline. Sum of scores=scoring×number of patients. Total score=sum of scores (cervical)+sum of scores (thoracic)+sum of scores (lumbosacral)
| Cervical | Thoracic | Lumbosacral | |||||
| Scoring | Number of patients (%) | Sum of scores | Number of patients (%) | Sum of scores | Number of patients (%) | Sum of scores | Cumulative score |
| Narrowing of the intervertebral space | |||||||
| 0 | 52 (37.7) | 0 | 40 (29.0) | 0 | 25 (18.1) | 0 | 0 |
| 1 | 38 (27.5) | 38 | 40 (29.0) | 40 | 16 (11.6) | 16 | 94 |
| 2 | 48 (34.8) | 96 | 58 (42.0) | 116 | 97 (70.3) | 194 | 406 |
| ≥1 | 86 (62.3) | 134 | 98 (71.0) | 156 | 113 (81.9) | 210 | 500 |
| Calcifications | |||||||
| 0 | 104 (75.4) | 0 | 36 (26.1) | 0 | 32 (23.2) | 0 | 0 |
| 1 | 32 (23.2) | 32 | 42 (30.4) | 42 | 29 (21.0) | 29 | 103 |
| 2 | 2 (1.4) | 4 | 60 (43.5) | 120 | 77 (55.8) | 154 | 278 |
| ≥1 | 34 (24.6) | 36 | 102 (73.9) | 162 | 106 (76.8) | 183 | 381 |
| Vacuum phenomena | |||||||
| 0 | 95 (68.8) | 0 | 96 (69.6) | 0 | 51 (37) | 0 | 0 |
| 1 | 16 (11.6) | 16 | 15 (10.9) | 15 | 23 (16.7) | 23 | 54 |
| 2 | 27 (19.6) | 54 | 27 (19.6) | 54 | 64 (46.4) | 128 | 236 |
| ≥1 | 43 (31.2) | 70 | 42 (30.5) | 69 | 87 (63.0) | 151 | 290 |
| Osteophytes/hyperostosis | |||||||
| 0 | 60 (43.5) | 0 | 46 (33.3) | 0 | 35 (25.4) | 0 | 0 |
| 1 | 60 (43.5) | 60 | 42 (30.4) | 42 | 35 (25.4) | 35 | 137 |
| 2 | 18 (13.0) | 36 | 50 (36.2) | 100 | 68 (49.3) | 136 | 272 |
| ≥1 | 78 (56.5) | 96 | 92 (66.7) | 142 | 103 (74.7) | 171 | 409 |
| Spinal fusions | |||||||
| 0 | 133 (96.4) | 0 | 119 (86.2) | 0 | 111 (80.4) | 0 | 0 |
| 1 | 3 (2.2) | 3 | 13 (9.4) | 13 | 11 (8.0) | 11 | 27 |
| 2 | 2 (1.4) | 4 | 6 (4.3) | 12 | 16 (11.6) | 32 | 48 |
| ≥1 | 5 (3.6) | 7 | 19 (13.8) | 25 | 27 (19.6) | 43 | 75 |