Table 4

Outcome parameters related to the number of non-DMARD medications taken in the previous 6 months

Parameters	Patients w/o non-DMARD drugs	OR (95% CI)*	P value	Patients w 1 or 2 non-DMARD drugs (reference)	Patients w ≥3 non-DMARD drugs	OR (95% CI)*	P value
n	443			565	298
No of non-DMARD medicines per patient	0			1.4 (0.5)	4.1 (1.3)
Age, years	23.2 (3.7)	1.00 (0.96 to 1.03)	0.790	23.3 (4.0)	24.5 (4.8)	1.07 (1.04 to 1.11)	<0.001
Female, N (%)	253 (57.1%)	0.59 (0.46 to 0.77)	<0.001	391 (69.2%)	242 (81.2%)	1.92 (1.37 to 2.70)	<0.001
Disease duration, years	13.4 (5.3)	0.99 (0.97 to 1.01)	0.293	13.7 (5.7)	15.8 (7.2)	1.06 (1.03 to 1.08)	<0.001
Patient-reported disease activity, (NRS 0–10)	1.9 (1.9)	0.77 (0.72 to 0.82)	<0.001	2.9 (2.2)	4.0 (2.3)	1.22 (1.14 to 1.29)	<0.001
Patient-reported pain, (NRS 0–10)	1.6 (1.9)	0.77 (0.72 to 0.82)	<0.001	2.7 (2.3)	3.9 (2.6)	1.21 (1.14 to 1.28)	<0.001
Patient-reported fatigue, (NRS 0–10)	2.4 (2.5)	0.89 (0.85 to 0.94)	<0.001	3.1 (2.6)	4.5 (2.8)	1.19 (1.13 to 1.25)	<0.001
HAQ total score (range 0–3)	0.1 (0.3)	0.33 (0.22 to 0.49)	<0.001	0.3 (0.5)	0.6 (0.7)	2.62 (2.04 to 3.37)	<0.001
Patient-reported HRQoL, SF-36, mental component summary score	50.7 (8.6)	1.02 (1.01 to 1.03)	0.004	49.0 (9.6)	48.0 (10.1)	0.99 (0.98 to 1.00)	0.147
Patient-reported HRQoL, SF-36, physical component summary score	51.5 (8.0)	1.06 (1.05 to 1.08)	<0.001	47.0 (9.6)	39.4 (11.7)	0.94 (0.93 to 0.95)	<0.001
Time from symptom onset to first bDMARD in years	4.8 (4.0)	0.97 (0.94 to 1.00)	0.086	5.3 (4.2)	6.3 (4.8)	1.05 (1.01 to 1.09)	0.005

The values are Mean (SD) unless indicated otherwise.
*OR from multinomial logistic regression in order to compare each parameter separately with the reference group ‘patients w 1 or 2 non-DMARD drugs’.
bDMARD, biological disease modifying antirheumatic drug; HAQ, Health Assessment Questionnaire; HRQoL, Health-related quality of life; NRS, Numerical Rating Scale; SF-36, Short Form-36; w, with; w/o, without.