Table 5

Summary of serious adverse events over the total follow-up duration

Patient n	Age years	Report at visit (month)	Event	Discontinuation of tocilizumab	Hospitalisation
Patient 5	42	12	Severe thrombocytopenia	No	No
Patient 39	45	6	Toe necrosis and infection	Yes	Yes
Patient 39	45	12	Pneumonitis (after stop of TCZ)	–	Yes
Patient 43	68	6	Atrial flutter	Yes	No
Patient 49	32	12	Digital ulcer with osteomyelitis	No	NA
Patient 50	41	3	Allergic reaction	Yes	No
Patient 50	41	3	Influenza	Yes	Yes
Patient 69	41	3	Renal crisis	Yes	Yes
Patient 69	41	6	Thrombophlebitis (after stop of TCZ)	–	Yes
Patient 70	58	6	Acute heart failure	Yes	NA
Patient 70	58	12	Amputation last phalanx Dig I foot (after stop of TCZ)	–	NA
Patient 71	76	6	Deep vein thrombosis	No	NA
Patient 80	56	0	Severe allergic reaction	Yes	NA
Patient 83	58	3	Bilateral keratitis	Yes	No
Patient 92	63	3	Pneumonia	No	Yes
Patient 92	63	12	Pneumonia	No	Yes
Patient 97	18	12	Sudden cardiac death	–	NA