Comparative analysis of PsA* patients regarding HLA-B27 status
| Total PsA* (N=474) | HLA-B27+ (N=86) | HLA-B27− (N=388) | Univariate analysis | Multivariate analysis | ||||||
| N/mean | %/SD | N/mean | %/SD | N/mean | %/SD | OR | P value | OR | P value | |
| Men | 234 | 49.4 | 49 | 57.0 | 185 | 47.7 | 1.45 (0.91–2.34) | 0.120 | n.s.* | |
| Family history | 178 | 37.6 | 44 | 51.2 | 134 | 34.5 | 1.99 (1.24–3.20) | 0.004 | 2.10 (1.26–3.52) | 0.004 |
| Age (year) | 51.0 | 13.0 | 48.2 | 12.7 | 51.6 | 13.0 | 0.98 (0.96–0.99) | 0.028 | n.s. | |
| Age onset (year) | 33.5 | 14.1 | 31.5 | 12.0 | 34.0 | 14.5 | 0.99 (0.97–1.00) | 0.152 | ||
| Age at diagnosis (year) | 43.3 | 13.1 | 38.7 | 12.5 | 44.3 | 13.1 | 0.97 (0.95–0.98) | <0.001 | n.s | |
| Diagnostic delay (month) | 9.8 | 11.5 | 7.1 | 9.5 | 10.4 | 11.8 | 0.97 (0.94–0.99) | 0.017 | 0.96 (0.93–0.99) | 0.005 |
| Disease duration (year) | 17.6 | 12.7 | 16.6 | 11.6 | 17.8 | 12.9 | 0.99 (0.97–1.01) | 0.443 | ||
| Mono/oligoarticular pattern | 188/416 | 45.2 | 31/74 | 41.9 | 157/342 | 45.9 | 0.85 (0.51–1.41) | 0.530 | ||
| Tarsitis | 53 | 11.2 | 13 | 15.1 | 40 | 10.3 | 1.55 (0.76–2.98) | 0.203 | ||
| Enthesitis | 225 | 47.5 | 44 | 51.2 | 181 | 46.6 | 1.20 (0.75–1.92) | 0.449 | ||
| Dactylitis | 172 | 36.3 | 30 | 34.9 | 142 | 36.6 | 0.93 (0.56–1.50) | 0.765 | ||
| Peripheral structural damage | 135 | 28.5 | 20 | 23.3 | 115 | 29.6 | 0.72 (0.41–1.22) | 0.237 | ||
| Axial involvement | 182 | 38.4 | 54 | 62.8 | 128 | 33.0 | 3.43 (2.12–5.62) | <0.001 | 3.48 (2.10–5.84) | <0.001 |
| Radiographic sacroilitis (AS* mNY* criteria fulfilment) | 98/423 | 23.2 | 31/77 | 40.3 | 67/346 | 19.4 | 3.03 (1.69–5.40) | <0.001 | n.s. | |
| Shoulder involvement | 76 | 16.0 | 14 | 16.3 | 62 | 16.0 | 1.02 (0.52–1.88) | 0.945 | ||
| Hip involvement | 64 | 13.5 | 16 | 18.6 | 48 | 12.4 | 1.62 (0.85–2.96) | 0.129 | n.s. | |
| Uveitis | 17 | 3.6 | 10 | 11.6 | 7 | 1.8 | 7.16 (2.67–20.29) | <0.001 | 8.03 (2.73–25.03) | <0.001 |
| If uveitis, no of episodes | 6.7 | 9.5 | 9.7 | 11.6 | 2.4 | 1.6 | 1.23 (0.99–2.22) | 0.270 | ||
| IBD* | 4 | 0.8 | 1 | 1.2 | 3 | 0.8 | 1.51 (0.07–11.96) | 0.723 | ||
| Fibromyalgia | 49 | 10.3 | 8 | 9.3 | 41 | 10.6 | 0.87 (0.37–1.83) | 0.728 | ||
AS, ankylosing spondylitis; IBD, inflammatory bowel disease; mNY, New York modified; ns, not significant; PsA, psoriatic arthritis.