Allelic association of the MUC5B rs35705950 SNP with RA-ILD and with RA-ILD subtypes
| n | MAF (T), % | Crude OR (95% CI) | Crude P value | Adjusted OR (95% CI)* | Adjusted P value* | |
| Patients with RA who have genotype data | 2444 | 0.37 | ||||
| Patients with RA who have chest CT | 683 | 0.81 | ||||
| RA-noILD | 578 | 0.69 | Reference | Reference | ||
| RA-ILD | 105 | 1.43 | 2.08 (0.55 to 7.90) | 0.282 | 2.46 (0.64 to 9.47) | 0.189 |
| UIP pattern | 63 | 2.38 | 3.50 (0.92 to 13.37) | 0.067 | 4.76 (1.22 to 18.60) | 0.025 |
| Other than UIP | 42 | 0 | NA | NA | NA | NA |
*The p values and OR (95% CI) were adjusted for age at RA diagnosis, which was significant clinical factors for RA-ILD in a multivariable model that considered age at RA diagnosis, sex, smoking, RF positivity and anti-CCP antibody positivity.
CCP, citrullinated cyclic peptide; MAF, minor allele frequency; NA, not available; noILD, without ILD; RA, rheumatoid arthritis; RA-ILD, rheumatoid arthritis associated interstitial lung disease; RF, rheumatoid factor; SNP, single nucleotide polymorphism; UIP, usual interstitial pneumonia.