Genotypic association of the MUC5B rs35705950 SNP with RA-ILD and with RA-ILD subtypes
| n | GG, n (%) | GT/TT, n (%) | Crude OR (95% CI) | Crude P value | Adjusted OR (95% CI)* | Adjusted P value* | |
| Patients with RA who have genotype data | 2444 | 2426 (99.3) | 18/0 (0.7) | ||||
| Patients with RA who have chest CT | 683 | 672 (98.4) | 11/0 (1.6) | ||||
| RA-noILD | 578 | 570 (98.6) | 8 (1.4) | Reference | Reference | ||
| RA-ILD | 105 | 102 (97.1) | 3 (2.9) | 2.10 (0.55 to 8.03) | 0.280 | 2.49 (0.64 to 9.69) | 0.187 |
| UIP pattern | 63 | 60 (95.2) | 3/0 (4.8) | 3.56 (0.92 to 13.79) | 0.066 | 4.90 (1.23 to 19.59) | 0.024 |
| Other than UIP | 42 | 42 (100) | 0/0 | NA | NA | NA | NA |
*The p values and OR (95% CI) were adjusted for age at RA diagnosis, which was significant clinical factors for RA-ILD in a multivariable model that considers age at RA diagnosis, sex, smoking, RF positivity and anti-CCP antibody positivity.
CCP, citrullinated cyclic peptide; noILD, without ILD; RA, rheumatoid arthritis; RA-ILD, rheumatoid arthritis associated interstitial lung disease; RF, rheumatoid factor; SNP, single-nucleotide polymorphism; UIP, usual interstitial pneumonia.