Genotype frequencies of FAM13A rs2609255 in the subpopulations of patients with RA
| n | Genotype | Recessive model for G allele | |||||
| (G/G) | (G/T) | (T/T) | P value | OR | 95% CI | ||
| Male | |||||||
| UIP (+) RA, n (%) | 42 | 19 (45.2) | 17 (40.5) | 6 (14.3) | 0.0088 | 3.37 | (1.43 to 7.95) |
| ILD (+) RA, n (%) | 79 | 25 (31.6) | 38 (48.1) | 16 (20.3) | 0.1299 | 1.89 | (0.87 to 4.08) |
| CLD (−) RA, n (%) | 66 | 13 (19.7) | 37 (56.1) | 16 (24.2) | |||
| Age >65 | |||||||
| UIP (+) RA, n (%) | 76 | 29 (38.2) | 25 (32.9) | 22 (28.9) | 0.0016 | 2.62 | (1.46 to 4.72) |
| ILD (+) RA, n (%) | 152 | 48 (31.6) | 57 (37.5) | 47 (30.9) | 0.0082 | 1.96 | (1.19 to 3.23) |
| CLD (−) RA, n (%) | 189 | 36 (19.0) | 102 (54.0) | 51 (27.0) | |||
| Male, age >65 | |||||||
| UIP (+) RA, n (%) | 39 | 18 (46.2) | 16 (41.0) | 5 (12.8) | 0.0407 | 3.29 | (1.10 to 9.84) |
| ILD (+) RA, n (%) | 67 | 24 (35.8) | 31 (46.3) | 12 (17.9) | 0.1592 | 2.14 | (0.77 to 5.98) |
| CLD (−) RA, n (%) | 29 | 6 (20.7) | 17 (58.6) | 6 (20.7) | |||
Genotype frequencies are shown in parentheses (%). Associations were tested in comparison with the CLD(-) RA population by Fisher's exact test using 2x2 contingency tables under the recessive model.
CLD, chronic lung disease; ILD, interstitial lung disease; RA, rheumatoid arthritis; UIP, usual interstitial pneumonia.