Genotype frequencies of FAM13A rs2609255 in the patients with RA in this study
| FAM13A | n | Genotype | Allele | Allele model | Recessive model for G allele | ||||||||
| rs2609255 | (G/G) | (G/T) | (T/T) | (G) | P value | Pc | OR | 95% CI | P value | Pc | OR | 95% CI | |
| UIP (+) RA, n (%) | 94 | 32 (34.0) | 35 (37.2) | 27 (28.7) | 99 (52.7) | 0.0092 | 0.0276 | 1.53 | (1.12 to 2.11) | 0.0003 | 0.0009 | 2.63 | (1.59 to 4.32) |
| NSIP (+) RA, n (%) | 114 | 23 (20.2) | 56 (49.1) | 35 (30.7) | 102 (44.7) | 0.4969 | 1.0000 | 1.12 | (0.83 to 1.50) | 0.4011 | 1.0000 | 1.29 | (0.76 to 2.17) |
| ILD (+) RA, n (%) | 208 | 55 (26.4) | 91 (43.8) | 62 (29.8) | 201 (48.3) | 0.0400 | 0.1200 | 1.29 | (1.02 to 1.63) | 0.0039 | 0.0117 | 1.83 | (1.22 to 2.73) |
| CLD (−) RA, n (%) | 420 | 69 (16.4) | 215 (51.2) | 136 (32.4) | 353 (42.0) | ||||||||
Genotype and allele frequencies are shown in parentheses (%). Associations were tested by Fisher's exact test using 2×2 contingency tables under the allele model or the recessive model.
CLD, chronic lung disease; ILD, interstitial lung disease; NSIP, non-specific interstitial pneumonia; RA, rheumatoid arthritis; UIP, usual interstitial pneumonia.