The demographical and clinical features between IgG4-RD patients with positive and negative AID family history.
| Paraments | AID-positive group (n=93) | AID-negative group (n=535) | P value |
| Age (years) | 50.4±14.8 | 54.2±12.6 | 0.014* |
| Male/female | 1.02:1 | 1.60:1 | 0.061 |
| Disease duration (months） | 18.0 (4.8, 36) | 12.0 (5.0, 36) | 0.382 |
| History of allergy, n (%) | 49 (92, 53.3) | 296 (533, 55.5) | 0.771 |
| Combine with other AID, n (%) | 15 (16.1) | 33 (6.2) | 0.0238* |
| IgG4-RD RI | 6 (4, 10) | 6 (4, 10) | 0.343 |
| Riedel thyroiditis, n (%) | 10 (92, 10.9) | 13 (532, 2.4) | 0.001* |
| Numbers of organs involvement | 3 (2, 4) | 3 (2, 4) | 0.613 |
| Cigarette smoking, n (%) | 29 (69, 42.0) | 192 (389, 49.4) | 0.321 |
| Continuous alcohol intake, n (%) | 3 (68, 4.4) | 19 (377, 5.0) | 1 |
*P<0.05
AID, autoimmune disease ; IgG4-RD, IgG4-related disease ; IgG4-RD RI, IgG4-RD responder index.