Table 1

Effect of surgery on epiphysial tibial trabecular microarchitecture in WT and NOX -/- mice

ParametersGenotypeNOX4 +/+NOX4 -/-Two-way ANOVAPairwise comparisons
ShamDMMShamDMMDMM effect
AbbreviationMeanSEMeanSEMeanSEMeanSEGenotype EffectDMM EffectIntNOX4 +/+NOX4 -/-
% of rp% of rp
Tibia trabecular epiphysial boneBone volume fractionBV/TV (%)42.193.7747.683.6646.942.9448.022.960.4490.3310.51113.010.3182.300.800
Trabecular numberTb.N (1 /mm)7.650.147.630.197.550.177.290.110.1690.3700.435−0.260.938−3.440.216
Trabecular separationTb.Sp (mm)96.05.195.65.395.43.192.93.60.6960.7240.807−0.490.950−2.660.597
Trabecular thicknessTb.Th (µm)139.61.9143.65.1140.53.2145.93.60.6580.1950.8592.900.4483.800.284
Connectivity densityConn.D (1/mm3)104.85.673.25.2100.17.790.74.30.2910.0020.074−30.160.001−9.450.296
Structure model indexSMI0.8500.330−0.0500.3900.2200.3100.2600.2500.6330.1870.150−105.880.09918.180.920
Tissue mineral densityTMD (mg HA/cm3)4837294823244785234790260.1120.8720.711−0.290.7230.110.877
  • Significant p values are marked in bold.

  • ANOVA, analysis of variance; DMM, destabilisation of the medial meniscus.