Table 2

Observed mean changes in PsA-modified vdH-S scores through week 100 in DISCOVER-2 patients evaluated in reading session 3*

Change in PsA-modified vdH-S scoreGuselkumab Q4WGuselkumab Q8WPlacebo (W0–24)→guselkumab Q4W (W24–100)
W0–24
N=221
W24–52
N=221
W52–100
N=211
W0–100
N=211
W0–24
N=228
W24–52
N=228
W52–100
N=216
W0–100
N=216
W0–24
N=215
W24–52
N=213
W52–100
N=202
W0–100
N=204
Total0.5 (2.7)0.6 (2.7)0.8 (4.0)1.7 (7.0)0.7 (2.4)0.3 (1.6)0.5 (2.4)1.5 (4.4)1.1 (3.8)0.3 (2.8)0.1 (3.7)1.5 (6.9)
Erosion0.3 (1.9)0.4 (1.8)0.4 (2.9)1.0 (4.7)0.5 (2.0)0.2 (1.2)0.3 (1.8)1.0 (3.4)0.7 (2.2)0.2 (1.8)0.1 (2.0)1.0 (4.0)
Joint space narrowing0.2 (1.2)0.2 (1.1)0.3 (1.3)0.7 (2.7)0.2 (0.7)0.1 (0.7)0.2 (0.9)0.5 (1.4)0.4 (1.7)0.1 (1.1)0.04 (1.9)0.5 (3.0)
  • Data presented as mean (SD).

  • *Reading session 3 included patients continuing study treatment at week 52 with images at weeks 0, 24, 52 and 100 (or at discontinuation after week 52).

  • PsA-modified vdH-S score, van der Heijde-Sharp score modified for psoriatic arthritis; Q4W, every 4 weeks; Q8W, every 8 weeks.