Demographic characteristics for both datasets
| Characteristic | Phase IIb dataset (N=190) | Pooled dataset (N=126) |
| Age | ||
| Mean (SD) | 50.1 (13.25) | 50.9 (12.9) |
| Median (Q1, Q3) | 52.0 (41.0, 59.0) | 51.5 (44.0, 61.0) |
| Min, max | 20, 75 | 23, 74 |
| Sex, n (%) | ||
| Female | 180 (94.7) | 113 (89.7) |
| Male | 10 (5.3) | 13 (10.3) |
| Race, n (%) | ||
| Asian | 22 (11.6) | 7 (5.6) |
| Black or African American | 1 (0.5) | 1 (0.8) |
| White | 165 (86.8) | 118 (93.7) |
| Other | 2 (1.1) | 0 (0.0) |
| Ethnicity, n (%) | ||
| Hispanic or Latino | 33 (17.4) | 2 (1.6) |
| Not Hispanic or Latino | 142 (74.7) | 30 (23.8) |
| Indian (Indian subcontinent) | 0 (0.0) | 4 (3.2) |
| Other (not specified) | 0 (0.0) | 90 (71.4)* |
| Missing | 15 (7.9) | 0 (0.0) |
*In CVAY736X2201 and CFZ533X2203, most patients selected ‘Other’ as these were international trials.