Risk of cancer in patients with psoriatic arthritis and age-matched and sex-matched controls
| No of cancers (%) | IR of cancers (/10 000 PYs) (95% CI) | HR (95% CI) | aHR (95% CI)* | |||
| PsA patients | Controls | PsA patients | Controls | |||
| Overall | 162 (3.45) | 1307 (2.79) | 83.2 (70.8 to 97.0) | 66.9 (63.3 to 70.6) | 1.24 (1.06 to 1.46) | 1.20 (1.02 to 1.41) |
| Overall excluding NMSC | 154 (3.28) | 1285 (2.74) | 79.1 (67.1 to 92.6) | 65.8 (62.2 to 69.5) | 1.20 (1.02 to 1.42) | 1.16 (0.98 to 1.37) |
| NMSC | 8 (0.17) | 22 (0.05) | 4.1 (1.8 to 8.1) | 1.1 (0.7 to 1.7) | 3.65 (1.62 to 8.19) | 3.64 (1.61 to 8.23) |
| Solid | 140 (2.99) | 1223 (2.61) | 71.9 (60.5 to 84.8) | 62.6 (59.2 to 66.2) | 1.15 (0.96 to 1.37) | 1.10 (0.93 to 1.32) |
| Thyroid | 24 (0.51) | 126 (0.27) | 12.3 (7.9 to 18.3) | 6.5 (5.4 to 7.7) | 1.91 (1.24 to 2.96) | 1.83 (1.18 to 2.85) |
| Stomach | 24 (0.51) | 162 (0.35) | 12.3 (7.9 to 18.3) | 8.3 (7.1 to 9.7) | 1.49 (0.97 to 2.28) | 1.40 (0.91 to 2.15) |
| Colorectal | 16 (0.34) | 161 (0.34) | 8.2 (4.7 to 13.3) | 8.2 (7.0 to 9.6) | 1.00 (0.60 to 1.66) | 0.96 (0.57 to 1.60) |
| Liver | 12 (0.26) | 101 (0.22) | 6.2 (3.2 to 10.8) | 5.2 (4.2 to 6.3) | 1.19 (0.65 to 2.17) | 1.09 (0.60 to 1.99) |
| Biliary | 8 (0.17) | 45 (0.10) | 4.1 (1.8 to 8.1) | 2.3 (1.7 to 3.1) | 1.78 (0.84 to 3.78) | 1.86 (0.87 to 3.95) |
| Pancreas | 4 (0.09) | 55 (0.12) | 2.1 (0.6 to 5.3) | 2.8 (2.1 to 3.7) | 0.73 (0.26 to 2.01) | 0.64 (0.23 to 1.77) |
| Lung | 13 (0.28) | 167 (0.36) | 6.7 (3.6 to 11.4) | 8.6 (7.3 to 10.0) | 0.78 (0.44 to 1.37) | 0.78 (0.44 to 1.37) |
| Breast | 11 (0.23) | 109 (0.23) | 5.7 (2.8 to 10.1) | 5.6 (4.6 to 6.7) | 1.01 (0.54 to 1.88) | 0.96 (0.51 to 1.79) |
| Prostate | 7 (0.15) | 56 (0.12) | 3.6 (1.5 to 7.4) | 2.9 (2.2 to 3.7) | 1.25 (0.57 to 2.75) | 1.24 (0.56 to 2.72) |
| Bladder | 3 (0.06) | 25 (0.05) | 1.5 (0.3 to 4.5) | 1.3 (0.8 to 1.9) | 1.20 (0.36 to 3.98) | 1.18 (0.35 to 3.93) |
| Kidney | 2 (0.04) | 27 (0.06) | 1.0 (0.1 to 3.7) | 1.4 (0.9 to 2.0) | 0.74 (0.18 to 3.12) | 0.69 (0.16 to 2.91) |
| Haematologic | 14 (0.30) | 62 (0.13) | 7.2 (3.9 to 12.1) | 3.2 (2.4 to 4.1) | 2.26 (1.27 to 4.04) | 2.24 (1.25 to 4.01) |
| Lymphoma | 10 (0.21) | 38 (0.08) | 5.1 (2.5 to 9.4) | 2.0 (1.4 to 2.7) | 2.64 (1.31 to 5.29) | 2.63 (1.30 to 5.30) |
| Leukaemia | 3 (0.06) | 14 (0.03) | 1.5 (0.3 to 4.5) | 0.7 (0.4 to 1.2) | 2.14 (0.62 to 7.46) | 2.19 (0.63 to 7.68) |
*Adjusted for age, sex, diabetes and hypertension.
aHR, adjusted HR ; IR, incidence rate; NMSC, non-melanoma skin cancer; No, number; PsA, psoriatic arthritis; PYs, person-years.