Comparisons of clinical and response features between ‘Rapid Responders’/‘Good Responders’ in the derivation cohort and those identified by nomogram models in the validation cohort
| ‘Rapid Responders’ in the derivation cohort | ‘Rapid Responders’ in the validation cohort | P value | ‘Good Responders’ in the derivation cohort | ‘Good Responders’ in the validation cohort | P value | |
| N (%) | 57 (29.4) | 28 (23.9) | 0.30 | 49 (25.3) | 19 (16.2) | 0.085 |
| Age/years | 39.60 (12.75) | 40.54 (10.02) | 0.61 | 33.12 (12.12) | 28.74 (6.85) | 0.283 |
| Male (%) | 7 (12.3) | 1 (3.6) | 0.37 | 4 (8.2) | 0 (0.0) | 0.478 |
| SLE duration/years | 3.69 (5.61) | 2.59 (3.67) | 0.236 | 4.10 (5.17) | 6.36 (5.27) | 0.02 |
| LN (%) | ||||||
| I or II | 5 (8.8) | 3 (10.7) | 0.947 | / | / | 0.509 |
| III | 18 (31.6) | 8 (28.6) | 9 (18.4) | 2 (10.5) | ||
| IV | 14 (24.6) | 7 (25.0) | 17 (34.7) | 6 (31.6) | ||
| Mixed | 11 (19.3) | 4 (14.3) | 17 (34.7) | 10 (52.6) | ||
| V | 9 (15.8) | 6 (21.4) | 6 (12.2) | 1 (5.3) | ||
| Albumin (g/L) | 30.92 (5.44) | 33.05 (5.49) | 0.164 | 23.91 (5.92) | 28.46 (5.51) | 0.002 |
| 24-hour urine protein (g/day) | 1.65 (1.24) | 1.80 (0.89) | 0.203 | 5.07 (3.47) | 3.30 (2.33) | 0.027 |
| eGFR (mL/min/1.73 m2) | 102.86 (28.95) | 102.12 (28.83) | 0.751 | 90.36 (35.36) | 104.77 (30.95) | 0.131 |
| Serum creatinine (umol/L) | 69.33 (31.27) | 68.66 (33.38) | 0.65 | 94.90 (75.24) | 71.32 (30.44) | 0.113 |
| Complete remission (%) | 48 (84.2) | 18 (64.3) | 0.073 | 39 (79.6) | 13 (68.4) | 0.512 |
| Time to complete remission/months* | 4.19 (3.45) | 4.86 (3.09) | 0.171 | 7.94 (5.36) | 6.62 (4.27) | 0.347 |
*Only those achieved CR was included in the analysis.
CR, complete remission; eGFR, estimated glomerular filtration rate; LN, lupus nephritis; SLE, systemic lupus erythematosus.