Predictive factors of 1-year ILD progression in IIM-ILD population
| Univariate analysis | Multivariate analysis | |||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Demographics | ||||
| Sex—(male vs female) | 1.34 (0.39 to 4.54) | 0.63 | – | – |
| Age at diagnosis ILD (years, ≥58 vs <58) | 0.50 (0.15 to 1.67) | 0.26 | – | – |
| Time from diagnosis to ILD—years | 0.87 (0.65 to 1.17) | 0.38 | – | – |
| Clinical features | ||||
| Mechanic’s hands (yes vs no) | 1.09 (0.26 to 4.48) | 0.90 | – | – |
| Heliotropic rash (yes vs no) | 8.00 (1.55 to 41.23) | 0.01 | 0.87 (0.13 to 5.65) | 0.88 |
| Xerostomia (yes vs no) | 8.19 (1.84 to 36.36) | 0.006 | 2.61 (0.23 to 28.6) | 0.43 |
| Xerophthalmia (yes vs no) | 8.00 (1.55 to 41.2) | 0.01 | 1.17 (0.08 to 16.1) | 0.90 |
| Muscle involvement | ||||
| MMT-8 | 0.99 (0.96 to 1.02) | 0.75 | – | – |
| CK | 1.00 (0.99 to 1.00) | 0.40 | – | – |
| Autoantibody profile | ||||
| Anti—MDA5 (yes vs no) | 6.10 (1.30 to 28.4) | 0.02 | 4.00 (0.53 to 29.8) | 0.17 |
| Radiological pattern | ||||
| NSIP (yes vs no) | 0.72 (0.19 to 2.73) | 0.63 | – | – |
| UIP (yes vs no) | 2.50 (0.68 to 9.08) | 0.16 | – | – |
| OP (yes vs no) | 0.50 (0.09 to 2.57) | 0.40 | – | – |
| Pulmonary function tests | ||||
| FVC (% pred.) | 1.02 (0.99 to 1.05) | 0.18 | – | – |
| FVC (L) | 1.95 (0.67 to 5.70) | 0.22 | – | – |
| DLCO (% pred.) | 1.07 (0.97 to 1.04) | 0.70 | – | – |
Values are expressed as OR (95%CI).
CK, creatine kinase; DLCO, diffusing capacity for carbon monoxide; FVC, forced vital capacity; IIM, idiopathic inflammatory myopathies; ILD, interstitial lung disease; MDA5, anti-melanoma differentiation-associated gene; MMT-8, manual muscle testing; NSIP, non-specific interstitial pneumonia; OP, organising pneumonia; UIP, usual interstitial pneumonia.