Table 1

Demographic and baseline disease characteristics

ParameterPBO
N=16
DAZ
3000 mg×1
N=16
DAZ
1500 mg×2
N=16
DAZ
3000 mg×2
N=15
DAZ
1500 mg×4
N=15
Total
N=78
Age, mean (SD)56.3 (14.0)53.2 (10.7)59.0 (12.2)56.5 (12.2)56.4 (15.2)56.3 (12.7)
Female, n (%)12 (75.0)14 (87.5)11 (68.8)13 (86.7)12 (80.0)62 (79.5)
Race, n (%)
 Black/African-American2 (12.5)001 (6.7)1 (6.7)4 (5.1)
 White14 (87.5)16 (100)15 (93.8)14 (93.3)14 (93.3)73 (93.6)
 Other001 (6.3)001 (1.3)
Ethnicity, n (%)
 Hispanic or Latino1 (6.3)1 (6.3)1 (6.3)003 (3.8)
 Non-Hispanic or Latino15 (93.8)15 (93.8)15 (93.8)15 (100)15 (100)75 (96.2)
BMI, mean (SD), kg/m227.6 (5.5)27.6 (3.8)28.0 (4.8)30.0 (6.0)30.1 (7.6)28.6 (5.6)
DAS28-CRP, mean (SD)5.4 (1.1)5.5 (0.9)5.9 (0.7)5.5 (0.6)5.8 (0.7)5.6 (0.8)
CRP, mean (SD), mg/mL17.6 (23.7)7.2 (12.4)14.9 (16.1)8.8 (9.2)14.1 (13.9)12.6 (16.0)
RF+, n (%)14 (87.5)12 (75.0)15 (93.8)12 (80.0)8 (53.3)61 (78.2)
CDAI, mean (SD)36.5 (10.5)39.0 (10.2)43.5 (10.7)35.7 (8.8)39.3 (8.8)38.9 (10.0)
SDAI, mean (SD)38.3 (11.6)39.7 (10.7)45.0 (10.8)36.6 (8.9)40.7 (9.3)40.1 (10.4)
TJC, mean (SD)13.3 (5.0)14.9 (5.1)17.5 (5.3)13.9 (4.1)15.3 (4.8)15.0 (5.0)
SJC, mean (SD)10.5 (4.0)9.8 (4.5)11.9 (5.1)9.3 (3.8)9.9 (4.1)10.3 (4.3)
PGA, mean (SD), mm VAS56.6 (21.2)71.3 (13.0)65.9 (18.9)64.6 (16.9)69.0 (16.4)65.4 (17.8)
MDGA, mean (SD), mm VAS71.0 (15.3)71.9 (12.6)75.3 (14.7)59.9 (18.3)72.4 (12.0)70.2 (15.3)
  • BMI, body mass index; CDAI, Clinical Disease Activity Index; CRP, C reactive protein; DAS28-CRP, Disease Activity Score in 28 joints using C reactive protein; DAZ, dazodalibep; MDGA, physician global assessment of disease activity; PBO, placebo; PGA, patient global assessment of disease activity; RF, rheumatoid factor; SDAI, Simplified Disease Activity Index; SJC, swollen joint count; TJC, tender joint count; VAS, visual analogue scale.