Failure to reach DAS28 remission at 3-month and 6-month follow-up, by comorbidity burden
| Measures of comorbidity burden | Proportion at 3 months n (%) | Proportion at 6 months n (%) | Not reaching DAS28 remission at 3 months n (%) | Not reaching DAS28 Remission at 6 months n (%) | Not reaching DAS28 remission at 3 months n=7643 RR (95% CI)* | Not reaching DAS28 remission at 6 months n=5391 RR (95% CI)* |
| RDCI: 0 | 5309 (69.5) | 3785 (70.2) | 2690 (50.7) | 2160 (57.1) | Reference | Reference |
| RDCI: 1 | 1101 (14.4) | 751 (13.9) | 624 (56.7) | 449 (59.8) | 1.15 (1.07 to 1.24) | 1.09 (0.99 to 1.20) |
| RDCI: 2 | 558 (7.3) | 397 (7.4) | 331 (59.3) | 227 (57.2) | 1.27 (1.14 to 1.41) | 1.07 (0.95 to 1.21) |
| RDCI: ≥3 | 675 (8.8) | 458 (8.5) | 374 (55.4) | 288 (62.9) | 1.19 (1.08 to 1.30) | 1.31 (1.16 to 1.49) |
| No of comorbidity categories: 0 | 3419 (44.7) | 2401 (44.5) | 1690 (49.4) | 1332 (55.5) | Reference | Reference |
| No of comorbidity categories: 1 | 2166 (28.3) | 1546 (28.7) | 1146 (52.9) | 895 (57.9) | 1.07 (1.02 to 1.14) | 1.07 (1.00 to 1.16) |
| No of comorbidity categories: 2 | 1248 (16.3) | 891 (16.5) | 710 (56.9) | 543 (60.9) | 1.20 (1.11 to 1.29) | 1.20 (1.09 to 1.31) |
| No of comorbidity categories: ≥3 | 810 (10.6) | 553 (10.3) | 473 (58.4) | 354 (64.0) | 1.27 (1.16 to 1.39) | 1.37 (1.21 to 1.54) |
Statistically significant findings are in bold.
*Adjusted for sex and age.
DAS28, 28-joint Disease Activity Score; RDCI, Rheumatic Disease Comorbidity Index; RR, relative risk.