Table 3

Univariate and multivariate prognostic analyses of risk factors in patients with IIM-ILD

UnivariateMultivariate
HR (95% CI)P valueHR (95% CI)P value
Disease duration (months)0.1
Age (years)1.032 (1.008, 1.057)0.0081.05 (1.02, 1.08)<0.001
Estimated ILD type2.55 (1.81, 3.59)<0.0012.02 (1.32, 3.1)0.001
Heliotrope sign1.86 (1.09, 3.2)0.02
Gottron’s sign0.06
Fever1.97 (1.15, 3.38)0.01
Anti-MDA53.9 (2.3, 6.8)<0.0012.88 (1.54, 5.37)0.001
RDW2.29 (1.33, 3.94)0.0032.9 (1.09, 7.67)0.03
Ferritin6.28 (2.88, 13.6)<0.001
LDH4.6 (1.8, 11.6)0.001
Decreased T cells3.67 (1.94, 7)<0.001
PaO2/FiO20.989 (0.987, 0.992)<0.0010.994 (0.990, 0.998)0.008
FVC%0.943 (0.927, 0.959)<0.001
DLco%0.937 (0.918, 0.957)<0.001
CRP2.2 (1.24, 3.94)0.007
ESR1.95 (1.07, 3.54)0.03
  • CRP, C reactive protein; DLco, carbon monoxide diffusion capacity; ESR, erythrocyte sedimentation rate; FVC, forced vital capacity; IIM, idiopathic inflammatory myopathy; ILD, interstitial lung disease; LDH, lactate dehydrogenase; MDA5, melanoma differentiation-associated gene 5; PaO2/FiO2, ratio of partial pressure of oxygen in arterial blood to the fraction of inspiratory oxygen concentration; RDW, red cell distribution width.