Table 2

Pregnancy outcome for pSS cases and control individuals

pSS (n=164)Controls (n=328)Adjusted OR95% CIP value
Fetal loss*36 (21.95%)12 (3.66%)
Spontaneous miscarriage21 (12.80%)5 (1.52%)11.335(4.128 to 31.123)<0.001
Duration of spontaneous miscarriage (day)†69.50±42.33155.43±30.48
Therapeutic miscarriage10 (6.10%)3 (0.91%)10.268(2.646 to 39.846)0.001
Other‡5 (3.05%)4 (1.22%)2.319(0.572 to 9.412)0.239
Oligohydramnios*26 (15.85%)35 (10.67%)1.672(0.936 to 2.989)0.083
Eclampsia/pre-eclampsia*2 (1.22%)5 (1.52%)0.319(0.042 to 2.430)0.270
Threatened preterm birth*7 (4.27%)3 (0.91%)3.896(0.925 to 16.412)0.064
Premature rupture of membranes*23 (14.02%)56 (17.07%)
Premature rupture of membranes in preterm16 (9.76%)50 (15.24%)0.728(0.391 to 1.356)0.317
Premature rupture of membranes in full term7 (4.27%)6 (1.83%)1.671(0.502 to 5.564)0.403
Placental abnormalities on ultrasound*24 (14.63%)21 (6.40%)2.295(1.182 to 4.457)0.014
 Placenta previa6 (3.66%)6 (1.83%)
 Placental abruption1 (0.61%)3 (0.91%)
 Hydatid mole1 (0.61%)0 (0%)
 Placenta implantation3 (1.83%)1 (0.30%)
 Placental adherence9 (5.49%)4 (1.22%)
 Placental thrombosis1 (0.61%)0 (0%)
 placental fibrin deposition6 (3.66%)0 (0%)
 Placental infarction1 (0.61%)0 (0%)
 Placental haematoma or bleeding5 (3.05%)5 (1.52%)
 Chorioamnionitis4 (2.44%)1 (0.30%)
 Veil-shaped placenta2 (1.22%)3 (0.91%)
 Racquet-shaped placenta2 (1.22%)1 (0.30%)
Pregnancy-induced hypertension*6 (3.66%)6 (1.83%)2.367(0.624 to 8.978)0.205
Gestational diabetes mellitus*18 (10.98%)27 (8.23%)1.339(0.673 to 2.666)0.406
  • Data were analysed by generalised linear regression method logistic.

  • *Number with the percentages between brackets.

  • †Mean±SD.

  • ‡Including stillbirth, ectopic pregnancy, hydatidiform mole.

  • n, number of deliveries; pSS, primary Sjögren’s syndrome.