Baseline characteristics
| TNFi strategy | Baricitinib strategy | |
| n=102 | n=97 | |
| Age (years), mean (SD) | 55.2 (13.4) | 54.8 (12.0) |
| Female, n (%) | 68 (66.7%) | 62 (63.9%) |
| Smoking, n (%) | ||
| Never | 38 (37.3%) | 37 (38.9%) |
| Stopped | 39 (38.2%) | 36 (37.9%) |
| Yes | 25 (24.5%) | 22 (23.2%) |
| BMI, mean (SD) kg/m2 | 27.4 (4.93) | 26.5 (5.03) |
| Disease duration (years), median (IQR) | 2.00(1.00; 3.00) | 2.00(1.00; 3.00) |
| Erosions state, n (%) | ||
| No | 66 (64.7%) | 69 (71.1%) |
| Unknown | 19 (18.6%) | 16 (16.3%) |
| Yes | 17 (16.7%) | 12 (12.4 |
| CV | ||
| No | 74 (72.5%) | 76 (78.4%) |
| Yes | 28 (27.5%) | 21 (21.6%) |
| Rheumatoid factor positive, n (%) | 69 (67.6%) | 70 (72.2%) |
| ACCP+, n (%) | 65 (63.7%) | 70 (72.2%) |
| Concomitant MTX, n (%) | 69 (67.6%) | 62 (63.9) |
| MTX dose, mg per week, mean (SD) | 19.9 (5.06) | 20.48 (5.42) |
| Glucocorticosteroid, n (average dose (mg)/day) | 16 (6.3) | 28 (7.7) |
| DAS28-ESR, mean (SD) | 4.43 (1.06) | 4.41 (1.14) |
| DAS28-CRP, mean (SD) | 4.17 (1.03) | 4.08 (1.05) |
| TJC, median (IQR) | 4.00 (2.00; 7.00) | 4.00 (2.00; 7.00) |
| SJC, median (IQR) | 3.00 (1.00; 5.00) | 3.00 (2.00; 4.00) |
| ESR, mm/hour, mean (SD) | 24.0 (19.5) | 25.1 (22.1) |
| CRP, mg/L mean (SD) | 13.7 (19.1) | 12.3 (17.5) |
| Physician global, mean (SD) | 50.0 (21.3) | 51.9 (16.9) |
| VAS wellbeing, mean (SD) | 61.1 (21.5) | 54.1 (22.5) |
| VAS pain, mean (SD) | 61.5 (24.0) | 55.6 (25.0) |
| RAPID 3 HAQ score, mean (SD) | 12.2 (5.66) | 10.9 (6.38) |
| CDAI, mean (SD) | 19.9 (8.68) | 19.6 (8.63) |
.ACCP, anticyclic citrullinated peptide antibody; BMI, body mass index; CDAI, Clinical Disease Activity Index; CRP, C reactive protein; CV, increased CardioVascular risk as reported by attending physician; ESR, erythrocyte sedimentation rate; MTX, methotrexate; PG, physician global; RAPID 3 HAQ, Rapid Health Assessment Questionnaire-II Health Assessment Questionnaire; SJC, swollen joint count; TJC, tender joint count; TNFi, tumour necrosis factor inhibitors; VAS, visual analogue scale.