Cognitive test results, anxiety and depression in patients with RA vs controls
| Variable | RA n=70 | Controls n=70 | P value |
| MoCA score, mean (SD) | 23.6 (3.9) | 25.1 (3.4) | 0.019 |
| Cognitive impairment (<26 MoCA), n (%) | 42 (60.0) | 28 (40.0) | 0.018 |
| Visuospatial, median (IQR) | 4.0 (2.7–5.0) | 4.0 (3.0–5.0) | 0.030 |
| Visuospatial achieved (5 p), n (%) | 23 (32.9) | 31 (44.3) | 0.165 |
| Identification, median (IQR) | 3.0 (3.0–3.0) | 3.0 (3.0–3.0) | 0.669 |
| Identification achieved (3 p), n (%) | 66 (94.3) | 67 (95.7) | 0.698 |
| Memory achieved, n (%) | 56 (80.0) | 65 (92.9) | 0.026 |
| Attention, median (IQR) | 4.0 (3.0–5.0) | 4.0 (3.0–6.0) | 0.127 |
| Attention achieved (6 p), n (%) | 20 (28.6) | 24 (34.3) | 0.466 |
| Language, median (IQR) | 2.0 (1.0–3.0) | 2.0 (1.0–3.0) | 0.244 |
| Language achieved (3 p), n (%) | 20 (28.6) | 31 (44.3) | 0.053 |
| Abstraction, median (IQR) | 1.5 (1.0–2.0) | 2.0 (1.0–2.0) | 0.038 |
| Abstraction achieved (2 p), n (%) | 39 (55.7) | 47 (67.1) | 0.165 |
| Delayed recall, median (IQR) | 2.0 (1.0–3.0) | 2.0 (1.0–5.0) | 0.526 |
| Delayed recall achieved (5 p), n (%) | 14 (20.0) | 19 (27.1) | 0.319 |
| Orientation, median (IQR) | 6.0 (6.0–6.0) | 6.0 (6.0–6.0) | 1.000 |
| Orientation achieved (6 p), n (%) | 70 (100.0) | 70 (100.0) | 1.000 |
| Forward digit span, mean (SD) | 5.9 (2.0) | 6.4 (1.9) | 0.165 |
| Backward digit span, mean (SD) | 4.0 (1.7) | 4.7 (1.9) | 0.039 |
| STROOP test | |||
| STROOP-W, mean (SD) | 93.5 (28.3) | 97.3 (25.5) | 0.455 |
| STROOP-C, mean (SD) | 74.7 (22.5) | 74.8 (22.3) | 0.987 |
| STROOP-WC, mean (SD) | 47.1 (19.0) | 45.2 (17.5) | 0.584 |
| HADS (depression), mean (SD) | 5.5 (3.3) | 3.0 (2.4) | <0.001 |
| Depression (HADS>11), n (%) | 9 (12.9) | 2 (2.9) | 0.028 |
| HADS (anxiety), mean (SD) | 7.7 (4.2) | 4.9 (3.6) | <0.001 |
| Anxiety (HADS>11), n (%) | 15 (21.4) | 4 (5.7) | 0.007 |
| QOL-RA-1, median (IQR) | 5.0 (3.0–6.0) | 8.0 (7.0–9.0) | <0.001 |
| QOL-RA-2, median (IQR) | 6.0 (4.0–8.0) | 8.0 (7.0–9.0) | <0.001 |
| QOL-RA-3, median (IQR) | 4.0 (3.0–6.0) | 9.0 (7.0–9.0) | <0.001 |
| QOL-RA-4, median (IQR) | 4.0 (3.0–6.0) | 8.0 (7.0–9.0) | <0.001 |
| QOL-RA-5, median (IQR) | 5.0 (3.0–6.0) | 8.0 (7.0–9.0) | <0.001 |
| QOL-RA-6, median (IQR) | 4.0 (3.0–6.0) | 9.0 (7.0–9.0) | <0.001 |
| QOL-RA-7, median (IQR) | 6.0 (3.0–7.5) | 9.0 (8.0–10.0) | <0.001 |
| QOL-RA-8, median (IQR) | 5.0 (3.0–7.0) | 9.0 (8.0–9.0) | <0.001 |
HADS, Hospital Anxiety and Depression Scale; MoCA, Montreal Cognitive Assessment; QOL-RA, Quality of Life-Rheumatoid Arthritis; STROOP-C, selective attention; STROOP-W, processing speed; STROOP-WC, inhibition.