Multivariate analysis of cognitive impairment in patients with RA
| Variable | Univariate OR (95%CI) | Multivariate OR* (95%CI) | P value |
| Age, years | 1.045 (1.001 to 1.090) | ||
| Female sex | 1.364 (0.405 to 4.590) | ||
| Educational level* | 0.335 (0.156 to 0.721) | 0.215 (0.081 to 0.568) | 0.002 |
| Obesity (BMI≥30) | 3.692 (1.081 to 12.060) | 5.998 (1.142 to 22.456) | 0.034 |
| Arterial hypertension | 3.000 (0.870 to 10.343) | ||
| Dyslipidaemia | 3.630 (0.954 to 14.622) | ||
| Depression (HADS) | 1.129 (0.952 to 1.340) | ||
| Average DAS28 | 2.022 (1.079 to 3.787) | 2.370 (1.051 to 5.342) | 0.037 |
| Average C-reactive protein | 1.080 (1.002 to 1.165) | 1.111 (1.002 to 0.568) | 0.045 |
Nagelkerke R2 = 0.422. The variables included in the equation were age, sex, educational level, obesity, average DAS28 and C-reactive protein.
*Educational level: secondary education or university compared with primary education.
BMI, body mass index; DAS28, 28-joint Disease Activity Score; HADS, Hospital Anxiety and Depression Scale; RA, rheumatoid arthritis.