Table 3

Parotid gland biopsy results

	PedSjD n=19	Diagnostic adSjD n=32	PedSjD versus diagnostic adSjD P value	Trial adSjD n=42	PedSjD versus trial adSjD P value
Focus score*	2.6 (1.3–3.4)	1.1 (0.3–1.8)†	*0.003*	1.82 (1.2–4.67)	0.79
Focus score ≥1, n (%)	16 (84.2)	21 (65.6)	0.20	36 (85.7)	1.00
CD45+ cells* (% of parenchyma)	20.4 (9.3–35)	10.35 (2.26–24.01)	*0.041*	16.3 (4.9–28.9)	0.46
LELs/mm²*	0.00 (0.00–0.29)	0.14 (0.00–0.26)	0.94	0.08 (0.00–0.35)	0.79
Presence of LELs, n (%)	9 (48)	18 (56)	0.54	23 (56)	0.53
LEL severity (1–3)*	2 (1–3)	2 (1–3)	0.87	1 (1–2)	0.27
CD21+ FDC networks/mm²*	0.21 (0.06–0.79)†	0.00 (0.00–0.35)	*0.029*	0.21 (0.00–0.46)	0.28
Bcl6+ ectopic GC/mm²*	0.14 (0.04–0.33)	0.00 (0.00–0.12)	*0.002*	0.00 (0.00–0.24)	*0.018*
CD3+ cells/mm²*	1384 (841–1883)	470 (177–1406)	*0.029*	715 (256–1917)	0.15
CD20+ cells/mm²*	1679 (428–2811)	376 (61–1003)	*0.004*	624 (108–1300)	*0.023*
CD20/(CD20+CD3) ratio*	0.51 (0.32–0.58)	0.39 (0.25–0.48)	*0.013*	0.40 (0.23–0.50)	*0.023*
CD3/CD20 segregation, n (%)	14 (74)	18 (56)	0.21	24 (57)	0.22
IgA/IgG plasma cell shift, n (%)	9 (47)	18 (56)	0.54	24 (57)	0.48
IgM+plasma cells/mm²*	68 (25–156)	42 (10–93)	0.09	29 (6–93)	*0.007*

Significant p values are italicised and bold.
*Data are reported as median (IQR) or n (%).
†Missing data: 0–5.
adSjD, adult-onset Sjögren’s disease; FDC, follicular dendritic cell; GC, germinal centre; IgA, immunoglobulin A; LEL, lymphoepithelial lesion; PedSjD, paediatric-onset Sjögren’s disease.