Laboratory results
| PedSjD n=19 | Diagnostic adSjD n=32 | PedSjD versus diagnostic adSjD P value | Trial adSjD n=42 | PedSjD versus trial adSjD P value | |
| IgG value, median (IQR), g/L | 16.1 (13.7–20.0)* | 16.6 (12.1–19.7) | 0.82 | 17.9 (13.2–23.5) | 0.39 |
| IgG elevated†, n (%) | 11 (64.7)* | 17 (53.1) | 0.44 | 27 (64.3) | 0.98 |
| RF-IgM value, median (IQR), IU/mL | 18 (1.7–73) | 23 (4–65)* | 0.67 | 23 (11.8–58.3) | 0.52 |
| RF+ (>5 IU/mL), n (%) | 12 (63.2) | 23 (74.2)* | 0.41 | 35 (83.3) | 0.08 |
| Anti-SSA+, n (%) | 13 (68.4) | 31 (96.9) | 0.004 | 36 (85.7) | 0.12 |
| Anti-SSB+, n (%) | 9 (47.4) | 15 (46.9) | 0.97 | 22 (52.4) | 0.72 |
| CRP>5, n (%), mg/L | 2 (10.5) | 9 (28.1) | 0.18 | 7 (16.7) | 0.71 |
| ESR>15, n (%), mm/hour | 6 (31.6) | 22 (68.8) | 0.010 | 28 (66.7) | 0.011 |
| C3<0.9, n (%), g/L | 0 (0) | 2 (6.5)* | 0.52 | 6 (14.3) | 0.16 |
| C4<0.1, n (%), g/L | 1 (5.3)* | 0 (0)* | 0.38 | 2 (4.8) | 1.00 |
| ANA+, n (%) | 16 (88.9) | 29 (90.6) | 1.00 | 29 (85.3) | 1.00 |
Significant p values are italicised and bold.
*Missing data: 0–5.
†IgG value elevated for age-related normal range.
adSjD, adult-onset Sjögren’s disease; ANA, antinuclear antibodies; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; IgG, immunoglobulin G; PedSjD, paediatric-onset Sjögren’s disease; RF, rheumatoid factor; SSA, Sjögren’s syndrome-related antigen A; SSB, Sjögren’s syndrome-related antigen B.