Parameters | Failure of complete response | Failure of complete or partial response | ||||||
Univariate | Multivariate | Univariate | Multivariate | |||||
Clinical | OR | P value | OR | 95% CI | OR | P value | OR | 95% CI |
Age | 1.02 | 0.21 | 1.03 | 0.15 | ||||
Male sex | 1.86 | 0.21 | 3.77 | 0.02 | 10.77 | 1.57 to 73.74 | ||
Hypertension | 1.72 | 0.20 | 2.69 | 0.06 | ||||
eGFR | 0.99 | 0.14 | 0.99 | 0.23 | ||||
Albumin | 0.61 | 0.14 | 0.61 | 0.25 | ||||
Low C3 | 0.34 | 0.04 | 0.51 | 0.10 to 2.44 | 0.23 | 0.02 | 0.55 | 0.05 to 6.06 |
Low C4 | 0.46 | 0.06 | 0.36 | 0.07 | ||||
High anti-dsDNA | 0.57 | 0.20 | 0.45 | 0.14 | ||||
UPr>3 g/24 hours | 2.50 | 0.03 | 1.44 | 0.49 to 4.21 | 1.22 | 0.70 | ||
Haematuria | 0.64 | 0.30 | 0.81 | 0.69 | ||||
Presence of casts | 2.65 | 0.05 | 1.44 | 0.56 | ||||
Histological | ||||||||
NIH AI | 1.01 | 0.82 | 0.90 | 0.17 | ||||
NIH CI | 1.52 | 0.004 | 1.57 | 1.15 to 2.14 | 2.08 | 0.001 | 2.26 | 1.35 to 3.77 |
Crescents >50% | 1.71 | 0.30 | ΝΑ | |||||
Interstitial inflammation | 1.88 | 0.13 | 1.10 | 0.85 | ||||
Interstitial fibrosis | 2.14 | 0.10 | 1.89 | 0.29 | ||||
Tubular atrophy | 2.44 | 0.06 | 9.56 | 0.03 | 0.94 | 0.08 to 11.39 |
Univariate and multivariate regression analysis between the association of baseline clinical and histological parameters and failure to achieve either complete or combined complete/partial response at 12 months. Parameters identified as statistically significant (at p<0.05, values in bold) in univariate analysis were entered in the multivariate model.
anti-dsDNA antibodies, antibodies against double stranded DNA; eGFR, estimated glomerular filtration rate; NIH AI, National Institutes of Health Activity Index; NIH CI, National Institutes of Health Chronicity Index; UPr, urine protein.