Table 2

An increased NIH Chronicity Index predicts failure to respond to immunosuppressive therapy at 12 months

ParametersFailure of complete responseFailure of complete or partial response
UnivariateMultivariateUnivariateMultivariate
ClinicalORP valueOR95% CIORP valueOR95% CI
Age1.020.211.030.15
Male sex1.860.213.770.0210.771.57 to 73.74
Hypertension1.720.202.690.06
eGFR0.990.140.990.23
Albumin0.610.140.610.25
Low C30.340.040.510.10 to 2.440.230.020.550.05 to 6.06
Low C40.460.060.360.07
High anti-dsDNA0.570.200.450.14
UPr>3 g/24 hours2.500.031.440.49 to 4.211.220.70
Haematuria0.640.300.810.69
Presence of casts2.650.051.440.56
Histological
 NIH AI1.010.820.900.17
 NIH CI1.520.0041.571.15 to 2.142.080.0012.261.35 to 3.77
 Crescents >50%1.710.30ΝΑ
 Interstitial inflammation1.880.131.100.85
 Interstitial fibrosis2.140.101.890.29
 Tubular atrophy2.440.069.560.030.940.08 to 11.39
  • Univariate and multivariate regression analysis between the association of baseline clinical and histological parameters and failure to achieve either complete or combined complete/partial response at 12 months. Parameters identified as statistically significant (at p<0.05, values in bold) in univariate analysis were entered in the multivariate model.

  • anti-dsDNA antibodies, antibodies against double stranded DNA; eGFR, estimated glomerular filtration rate; NIH AI, National Institutes of Health Activity Index; NIH CI, National Institutes of Health Chronicity Index; UPr, urine protein.