Table 2

Top-10 deregulated genes in TABs

TMI versus NEG			TMI versus ILA			ILA versus NEG
Gene	FC	BY P value	Gene	FC	BY P value	Gene	FC	MW p value*
CXCL9	71.4	0.000001	CCL18	19.0	0.000019	CXCL9	3.9	0.011072
CCL18	58.9	0.000001	CXCL9	18.1	0.000063	CD163	3.8	0.011072
SPP1	43.1	0.000036	CHIT1	14.9	0.000146	IL7R	3.7	0.037879
CHIT1	31.4	0.000011	SPP1	12.7	0.002058	GZMK	3.7	0.026224
MARCO	18.4	0.000011	MARCO	11.6	0.000047	GZMA	3.6	0.004079
ITGB2	16.5	0.000001	CCL19	10.7	0.000012	IL2RG	3.3	0.006993
C1QB	15.7	0.000001	CYBB	7.7	0.000019	CR1	3.2	0.011072
LTB	15.5	0.000001	IDO1	7.4	0.000012	CCL18	3.1	0.026224
ITGAX	15.3	0.000001	CD74	7.4	0.000012	CD53	3.1	0.026224
CYBB	15.0	0.000001	IL2RB	7.3	0.000012	FCGR3A	2.9	0.011072
MCAM	−9.8	0.000001	MCAM	−6.9	0.000146
RRAD	−7.5	0.000050	RRAD	−5.2	0.000374
TGFB2	−5.1	0.000003	MFGE8	−4.9	0.000012
MFGE8	−4.9	0.000001	CX3CL1	−4.5	0.000063
CYFIP2	−4.3	0.000001	CYFIP2	−3.9	0.000146
CX3CL1	−4.2	0.000018	PDGFRB	−3.3	0.000842
CFD	−4.1	0.000790	TGFB2	−3.3	0.001453
PPBP	−3.8	0.020432	LRRN3	−3.3	0.000146
JAM3	−3.7	0.000001	JAM3	−3.2	0.000012
IGF1R	−3.7	0.000001	CCL14	−3.1	0.004051

*Uncorrected p values resulting from Mann-Whitney test.
BY, Benjamini-Yekutieli ; FC, fold changes; ILA, inflammation limited to adventitia; NEG, normal temporal artery biopsies without inflammation from patients without GCA; TABs, temporal artery biopsies; TMI, transmural inflammation.